Environmental agents affect skeletal growth and development.

Environmental agents affect skeletal growth and development. Research Abstract Details 

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Environmental agents affect skeletal growth and development. Abstract Text:

Jonathan D Holz,Tzong-jen Sheu,Hicham Drissi,Mitsuhiro Matsuzawa,Michael J Zuscik,J Edward Puzas,

In this treatise we will examine complexities in the development and function of cells of the musculoskeletal system. Specifically, the role of chondrocytes and their ontogeny and osteoblasts and their ontogeny will be discussed as they regulate cartilage and bone formation. This background information will provide the foundation for evaluating the effects of environmental toxicants on skeletal development. A number of agents such as heavy metals (i.e. lead) and polycyclic aromatic hydrocarbons (i.e. pesticides and cigarette smoke) interact with cells of the skeletal system and adversely affect development. These agents have not been of major research interest, nevertheless, given changes in the environmental profile of the United States and other developed countries, it is important that we understand their effects in bone and cartilage. Research in this area will identify strategies that may be used to help prevent musculoskeletal diseases due to toxicant exposure.

Environmental agents affect skeletal growth and development. Publishing Authors By Initials

JD Holz,TJ Sheu,H Drissi,M Matsuzawa,MJ Zuscik,JE Puzas,

For similar proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research abstracts see: proteins: receptors, cytoplasmic and nuclear: receptors, aryl hydrocarbon research

PUBMED ID PMID:

MEDLINE DATE:

Environmental agents affect skeletal growth and development. Journal Published:

PUBLICATION TYPE: Review

Journal: Birth defects research. Part C, Embryo today : rev

VOLUME: 81

Page Numbers: 41-50

Journal Abbreviation: Birth Defects Res. C Embryo To

ISSN: 1542-975X

DAY: 3

MONTH: Mar

YEAR: 2007

Environmental agents affect skeletal growth and development. Information

Number of References: 81

LANGUAGE: eng

NlmUniqueID: 101167665

Environmental agents affect skeletal growth and development. Keywords Mesh Terms:

KEYWORDS: Receptors, Aryl Hydrocarbon

MESH TERMS: metabolism

Chemical & Substance for Abstract: Environmental agents affect skeletal growth and development. Information

Substance Name: Receptors, Aryl Hydrocarbon

Registry Number: 0

Grant and Affiliation Information for Environmental agents affect skeletal growth and development.

AFFILIATION: Department of Orthopaedics and the Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: P30 ES01247

ACRONYM: ES

MEDLINETA: Birth Defects Res C Embryo Tod

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