Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue.

Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue. Research Abstract Details 

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Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue. Abstract Text:

Natasha Wright,Lisa Samuelson,Maggie H Walkup,Prakash Chandrasekaran,David A Gerber,Natasha Wright,Lisa Samuelson,Maggie H Walkup,Prakash Chandrasekaran,David A Gerber,Natasha Wright,Lisa Samuelson,Maggie H Walkup,Prakash Chandrasekaran,David A Gerber,Natasha Wright,Lisa Samuelson,Maggie H Walkup,Prakash Chandrasekaran,David A Gerber,

BACKGROUND/AIM: Recent interest in the liver stem cell field has led to the identification and characterization of several hepatic progenitor cell populations from fetal and adult tissues. We isolated a hepatic progenitor cell from naïve adult liver and the current studies focus on differentiation and growth. RESULTS: A Sca-1(+) hepatic progenitor cell was identified within the liver parenchyma. This cell expresses numerous liver related genes and transcription found in the developing and/or adult liver. It is located in the peri-portal region and expresses markers associated with undifferentiated hepatic cell populations, mature hepatocytes and biliary cells which distinguish it from the Sca-1(-) fraction. CONCLUSION: This hepatic progenitor cell from uninjured liver has features of both hepatocytic and biliary populations and demonstrates proliferative potential. Further studies will focus on sca-HPC subsets and conditions that regulate differentiation towards hepatic or biliary lineages.

Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue. Publishing Authors By Initials

N Wright,L Samuelson,MH Walkup,P Chandrasekaran,DA Gerber,N Wright,L Samuelson,MH Walkup,P Chandrasekaran,DA Gerber,N Wright,L Samuelson,MH Walkup,P Chandrasekaran,DA Gerber,N Wright,L Samuelson,MH Walkup,P Chandrasekaran,DA Gerber,

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Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 366

Page Numbers: 367-72

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 4

MONTH: 12

YEAR: 2007

Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Enrichment of a bipotent hepatic progenitor cell from naïve adult liver tissue.

AFFILIATION: Department of Surgery, University of North Carolina, CB#7211, 4024 Burnett-Womack Building, Chapel Hill, NC 27599-7211, USA.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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