Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.

Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Research Abstract Details 

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Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Abstract Text:

David A Costa,Jennifer R Cracchiolo,Adam D Bachstetter,Tiffany F Hughes,Kelly R Bales,Steven M Paul,Ronald F Mervis,Gary W Arendash,Huntington Potter,

Lifelong cognitive stimulation is associated with a lower risk of Alzheimer's disease (AD), but causality is difficult to prove. We therefore sought to investigate the preventative potential of environmental enrichment (EE) using mice expressing both human mutant presenilin-1 and the amyloid precursor protein (PS1/PDAPP). At weaning, mice were placed into either an enriched or standard housing environment. Behavioral testing at 4.5-6 months showed that environmentally enriched PS1/PDAPP mice outperformed mice in standard housing, and were behaviorally indistinguishable from non-transgenic mice across multiple cognitive domains. PS1/PDAPP mice exposed to both environmental enrichment and behavioral testing, but not to EE alone, showed 50% less brain beta-amyloid without improved dendritic morphology. Microarray analysis revealed large enrichment-induced changes in hippocampal expression of genes/proteins related to Abeta sequestration and synaptic plasticity. These results indicate that EE protects against cognitive impairment in AD transgenic mice through a dual mechanism, including both amyloid dependent and independent mechanisms.

Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Publishing Authors By Initials

DA Costa,JR Cracchiolo,AD Bachstetter,TF Hughes,KR Bales,SM Paul,RF Mervis,GW Arendash,H Potter,

For similar investigative techniques: clinical laboratory techniques: cytological techniques: histocytological preparation techniques: staining and labeling: silver staining research abstracts see: investigative techniques: clinical laboratory techniques: cytological techniques: histocytological preparation techniques: staining and labeling: silver staining research

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Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 831-44

Journal Abbreviation:

ISSN: 1558-1497

DAY: 26

MONTH: 05

YEAR: 2006

Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100437

Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Keywords Mesh Terms:

KEYWORDS: Silver Staining

MESH TERMS: methods

Chemical & Substance for Abstract: Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms. Information

Substance Name: Rolipram

Registry Number: 61413-54-5

Grant and Affiliation Information for Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms.

AFFILIATION: Johnnie B. Byrd Sr. Alzheimer's Center and Research Institute, Tampa, FL 33647, USA.

Country: United States

AGENCY: United States NIA

GRANT: P50AG025711

ACRONYM: AG

MEDLINETA: Neurobiol Aging

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