Enhancing the recognition of tumour associated antigens.

Enhancing the recognition of tumour associated antigens. Research Abstract Details 

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Enhancing the recognition of tumour associated antigens. Abstract Text:

N P Restifo,B R Minev,A S Taggarse,B J McFarland,M Wang,K R Irvine,

Activated CD8+ T cells (TCD8+) can directly recognize malignant cells because processed fragments of tumour associated antigens (TAA), 8-10 amino acids in length and complexed with MHC class I molecules, are displayed on tumour cell surfaces. Tumour cells have been genetically modified in a variety of ways in efforts to enhance the immune recognition of TAA. An alternative strategy is the expression of TAA in recombinant or synthetic form. This has been made possible by the recent cloning of TAA recognized by TCD8+. In this communication we review recent work in our own laboratory on the expression of TAA as synthetic peptide, by "naked" plasmid DNA injected intramuscularly or transdermally, and by recombinant viruses including vaccinia (rVV), fowlpox (rFV) and adenovirus (rAd). The expression of TAA in recombinant and synthetic forms allows increased control over the quantity, location, and kinetics of TAA presentation and can result in powerful, specific, anti-tumour immune responses.

Enhancing the recognition of tumour associated antigens. Publishing Authors By Initials

NP Restifo,BR Minev,AS Taggarse,BJ McFarland,M Wang,KR Irvine,

For similar proteins: recombinant proteins research abstracts see: proteins: recombinant proteins research

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Enhancing the recognition of tumour associated antigens. Journal Published:

PUBLICATION TYPE: Review

Journal: Folia biologica

VOLUME: 40

Page Numbers: 74-88

Journal Abbreviation: Folia Biol. (Praha)

ISSN: 0015-5500

DAY: 28

MONTH: 01

YEAR: 1994

Enhancing the recognition of tumour associated antigens. Information

Number of References: 69

LANGUAGE: eng

NlmUniqueID: 234640

Enhancing the recognition of tumour associated antigens. Keywords Mesh Terms:

KEYWORDS: Recombinant Proteins

MESH TERMS: immunology

Chemical & Substance for Abstract: Enhancing the recognition of tumour associated antigens. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Enhancing the recognition of tumour associated antigens.

AFFILIATION: Surgery Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Country: CZECH REPUBLIC

AGENCY: United States NCI

GRANT: Z01 BC010763-01

ACRONYM: BC

MEDLINETA: Folia Biol (Praha)

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