Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate.

Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Research Abstract Details 

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Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Abstract Text:

Benjamin Chiang,Eric Essick,William Ehringer,Sidney Murphree,Mary Anne Hauck,Ming Li,Sufan Chien,

BACKGROUND: A new intracellular adenosine triphosphate (ATP) delivery technique has been developed and was tested for skin wound care. METHODS: Eleven pairs of adult nude mice were used. ATP-vesicles were applied in 11 mice, and another 11 mice were treated with lipid vesicles only. RESULTS: The group treated with ATP-encapsulated fusogenic small, unilamellar lipid vesicles healed faster than the group treated with only lipid vesicles. Histologic study indicated better developed granular tissue and re-epithelialization in the study group, and wound tissue vascular endothelial growth factor expressions were also higher in ATP-vesicles treated mice. CONCLUSIONS: This intracellular ATP delivery system may provide a new hope for wound healing as well as the treatment of medical conditions in which ischemia is involved.

Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Publishing Authors By Initials

B Chiang,E Essick,W Ehringer,S Murphree,MA Hauck,M Li,S Chien,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of surgery

VOLUME: 193

Page Numbers: 213-8

Journal Abbreviation: Am. J. Surg.

ISSN: 0002-9610

DAY: 12

MONTH: Feb

YEAR: 2007

Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370473

Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: drug effects

Chemical & Substance for Abstract: Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate. Information

Substance Name: Adenosine Triphosphate

Registry Number: 56-65-5

Grant and Affiliation Information for Enhancing skin wound healing by direct delivery of intracellular adenosine triphosphate.

AFFILIATION: Department of Surgery, University of Louisville, Louisville, KY 40202, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R56 DK074566-01

ACRONYM: DK

MEDLINETA: Am J Surg

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