Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo.

Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo. Research Abstract Details 

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Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo. Abstract Text:

Cardiac myocytes are the first cells to differentiate during the development of a vertebrate embryo. A wide variety of molecules take part in various steps in this process. While exploring biologically active molecules from marine sources, we found that a constituent of perivitelline fluid from embryos of the Indian horseshoe crab can enhance growth and differentiation of chick embryonic heart. We have purified the factor and identified the cardiac promoting molecule to be a novel lectin. We show that this molecule influences cardiac development by increasing the number of cells constituting the heart and by modulating the expression of several cardiac development regulatory genes in chick embryos. Using mouse embryonic stem cells we show that the cardiac myocyte-enhancing capacity of this molecule extends to mammals and its effects can be blocked using methylated sugars. This molecule may prove to be an important tool in the study of cardiomyocyte differentiation.

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Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cellular and molecular life sciences : CMLS

VOLUME: 65

Page Numbers: 3312-24

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ISSN: 1420-682X

DAY: 13

MONTH: Oct

YEAR: 2008

Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo. Information

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LANGUAGE: eng

NlmUniqueID: 9705402

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Grant and Affiliation Information for Enhancement of vertebrate cardiogenesis by a lectin from perivitelline fluid of horseshoe crab embryo.

AFFILIATION: Agharkar Research Institute, G.G. Agarkar Road, Pune, 411 004, India, ghaskadbi@gmail.com.

Country: Switzerland

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MEDLINETA: Cell Mol Life Sci

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