Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide.

Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Research Abstract Details 

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Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Abstract Text:

R G Overcash,J R Lindsey,G H Cassel,H J Baker,

Hexamethylphosphoramide (HMPA) was given orally (100 mg/kg/day) to: a) conventional rats of Sprague-Dawley and Long-Evans substrains known to have indigenous Mycoplasma pulmonis infection, b) uninfected pathogen-free (PF) Fischer rats, and c) PF and axenic Fischer rats inoculated intranasally with M. pulmonis strains having a wide range of virulence. Treated rats infected with virulent M. pulmonis, either naturally or experimentally, developed severe clinical signs of murine respiratory mycoplasmosis (MRM) with mortalities of 25 to 60% compared to relatively mild MRM and no deaths in untreated, infected controls. Deaths were attributed to unusually severe lung lesions of MRM (extreme neutrophilic exudation into major bronchi and bronchiectasis) with ulceration of respiratory mucosa and hemorrhage. Rhinitis also was increased in severity by HMPA in conventional rats, but not in experimentally infected PF or axenic rats. Severity of otitis media and tracheitis was not affected by HMPA. Incidence of lesions of MRM was unchanged except for increased frequency of gross lung lesions. In the absence of M. pulmonis infection, HMPA treatment of rats caused thinning and microulceration of respiratory epithelium in major bronchi without inflammatory lung disease. Other effects induced by HMPA, with or without the infection, were destruction and fibrous replacement of olfactory epithelium, atrophy of testes, and reduced weight gains. It was concluded that HMPA markedly enhances both rate of progression and severity of the pneumonia while inconsistently potentiating the rhinitis of MRM in rats. Previous studies of HMPA are emphasized as an additional example in which the synergistic effects of an experimental chemical and an indigenous pathogen of laboratory rats have given misleading experimental results.

Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Publishing Authors By Initials

RG Overcash,JR Lindsey,GH Cassel,HJ Baker,

For similar respiratory system: trachea research abstracts see: respiratory system: trachea research

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Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The American journal of pathology

VOLUME: 82

Page Numbers: 171-90

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 20

MONTH: Jan

YEAR: 1976

Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Information

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LANGUAGE: eng

NlmUniqueID: 370502

Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Keywords Mesh Terms:

KEYWORDS: Trachea

MESH TERMS: pathology

Chemical & Substance for Abstract: Enhancement of natural and experimental respiratory mycoplasmosis in rats by hexamethylphosphoramide. Information

Substance Name: Hempa

Registry Number: 680-31-9

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Country: UNITED STATES

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MEDLINETA: Am J Pathol

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