Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells.

Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Research Abstract Details 

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Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Abstract Text:

Elisabeth H Javazon,Sundeep G Keswani,Andrea T Badillo,Timothy M Crombleholme,Philip W Zoltick,Antoneta P Radu,Elliot D Kozin,Kirstin Beggs,Asim A Malik,Alan W Flake,

The direct application of bone marrow (BM) can accelerate the healing of chronic wounds. We hypothesized that this effect is due to the presence of stromal progenitor cells (SPCs) found within whole BM preparations. To test this hypothesis, we isolated adult murine SPCs from whole BM and examined their ability to enhance impaired wound healing compared with ficoll separated BM cells in the diabetic (db/db) mouse model. SPCs significantly enhanced reepithelialization, granulation tissue formation, and neovascularization compared with control wounds treated with BM or PBS alone. Higher frequencies of donor SPC cells compared with donor BM cells were observed in treated wounds at 7 days. Transdifferentiation into GFP-positive mature endothelial cells was not observed. These observations suggest that SPCs improve wound healing through indirect mechanisms which lead to enhanced vascularization rather than through direct participation and incorporation into tissue. We conclude that topical application of BM-derived SPCs may represent an effective strategy for the treatment of chronic diabetic wounds.

Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Publishing Authors By Initials

EH Javazon,SG Keswani,AT Badillo,TM Crombleholme,PW Zoltick,AP Radu,ED Kozin,K Beggs,AA Malik,AW Flake,

For similar disorders of environmental origin: wounds and injuries research abstracts see: disorders of environmental origin: wounds and injuries research

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Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Wound repair and regeneration : official publicati

VOLUME: 15

Page Numbers: 350-9

Journal Abbreviation:

ISSN: 1067-1927

DAY: 3

MONTH: 12

YEAR: 2007

Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Information

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LANGUAGE: eng

NlmUniqueID: 9310939

Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Keywords Mesh Terms:

KEYWORDS: Wounds and Injuries

MESH TERMS: therapy

Chemical & Substance for Abstract: Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells. Information

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Grant and Affiliation Information for Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells.

AFFILIATION: Department of Surgery, The Children's Center for Fetal Research, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Country: United States

AGENCY: United States NICHD

GRANT: T32 HD046402

ACRONYM: HD

MEDLINETA: Wound Repair Regen

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