Enhanced effect of high-dose leukocytapheresis using a large filter in rheumatoid arthritis.

Enhanced effect of high-dose leukocytapheresis using a large filter in rheumatoid arthritis. Research Abstract Details 

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Enhanced effect of high-dose leukocytapheresis using a large filter in rheumatoid arthritis. Abstract Text:

Katsumi Eguchi,Kazuyoshi Saito,Masakazu Kondo,Toshihiko Hidaka,Yukitaka Ueki,Yoshiya Tanaka, ,Katsumi Eguchi,Kazuyoshi Saito,Masakazu Kondo,Toshihiko Hidaka,Yukitaka Ueki,Yoshiya Tanaka, ,Katsumi Eguchi,Kazuyoshi Saito,Masakazu Kondo,Toshihiko Hidaka,Yukitaka Ueki,Yoshiya Tanaka, ,

To evaluate the efficacy of high-dose leukocytapheresis (LCAP) using a large filter in patients with refractory rheumatoid arthritis (RA), we conducted a multicenter, nonrandomized, open-label clinical study. Thirty patients with highly active RA were treated with high-dose LCAP performed 3-5 sessions at 1-week intervals using a CS-180S filter (CS-180S group); the treatment involves the removal of leukocytes from a higher blood volume per body weight (100;Sml/kg). The clinical response was evaluated at 4 and 8 weeks after a series of LCAP using the 28-joint disease activity score (DAS28). Similar data of 53 patients treated with conventional LCAP (60;Sml/kg) using a standard filter, CS-100, were compared as a control (CS-100 group). The CS-180S filter demonstrated a higher adsorption capacity for leukocytes, particularly lymphocytes. The CS-180S group exhibited significant improvements in each item of DAS28 after treatment although the CS-100 group did not demonstrate such improvements in the CRP level and the ESR. Compared to the CS-100 group, the patients of the CS-180S group exhibited a tendency toward improvement with respect to the CRP level and ESR (P = 0.057 and 0.041, respectively). According to the EULAR improvement criteria based on DAS28, 60% and 45% of the patients from CS-180S and CS-100 groups achieved moderate or more responses, respectively, at 4 weeks after treatment. These results suggest that compared to conventional LCAP, high-dose LCAP may enhance the suppression of RA disease activity.

Enhanced effect of high-dose leukocytapheresis using a large filter in rheumatoid arthritis. Publishing Authors By Initials

K Eguchi,K Saito,M Kondo,T Hidaka,Y Ueki,Y Tanaka, ,K Eguchi,K Saito,M Kondo,T Hidaka,Y Ueki,Y Tanaka, ,K Eguchi,K Saito,M Kondo,T Hidaka,Y Ueki,Y Tanaka, ,

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Enhanced effect of high-dose leukocytapheresis using a large filter in rheumatoid arthritis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Modern rheumatology / the Japan Rheumatism Associa

VOLUME: 17

Page Numbers: 481-5

Journal Abbreviation: Mod Rheumatol

ISSN: 1439-7595

DAY: 20

MONTH: 12

YEAR: 2007

Enhanced effect of high-dose leukocytapheresis using a large filter in rheumatoid arthritis. Information

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LANGUAGE: eng

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AFFILIATION: First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

Country: Japan

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MEDLINETA: Mod Rheumatol

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