Engulfment of apoptotic cells: signals for a good meal.

Engulfment of apoptotic cells: signals for a good meal. Research Abstract Details 

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Engulfment of apoptotic cells: signals for a good meal. Abstract Text:

Kodi S Ravichandran,Ulrike Lorenz,Kodi S Ravichandran,Ulrike Lorenz,

The clearance of apoptotic cells by phagocytes is an integral component of normal life, and defects in this process can have significant implications for self tolerance and autoimmunity. Recent studies have provided new insights into the engulfment process, including how phagocytes seek apoptotic cells, how they recognize and ingest these targets and how they maintain cellular homeostasis after the 'meal'. Several new factors that regulate engulfment have been identified, whereas the roles of some of the older players require revision. This Review focuses on these recent developments and attempts to highlight some of the important questions in this field.

Engulfment of apoptotic cells: signals for a good meal. Publishing Authors By Initials

KS Ravichandran,U Lorenz,KS Ravichandran,U Lorenz,

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Engulfment of apoptotic cells: signals for a good meal. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nature reviews. Immunology

VOLUME: 7

Page Numbers: 964-74

Journal Abbreviation: Nat. Rev. Immunol.

ISSN: 1474-1741

DAY: 26

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101124169

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Grant and Affiliation Information for Engulfment of apoptotic cells: signals for a good meal.

AFFILIATION: Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, Virginia, 22908, USA. ravi@virginia.edu

Country: England

AGENCY: United States NIGMS

GRANT: GM069998

ACRONYM: GM

MEDLINETA: Nat Rev Immunol

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