Engineering productive enzyme confinement.

Engineering productive enzyme confinement. Research Abstract Details 

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Engineering productive enzyme confinement. Abstract Text:

A Keith Dunker,Ariel ,

Natural enzymes were selected to function inside the cell, not in the test tube; therefore, their performance is optimized for the crowded conditions encountered in vivo. Most man-made matrices for enzyme confinement lead to suboptimal catalytic activity. Ackerman and colleagues showed that an entrapping environment consisting of functionalized mesoporous silica actually enhances enzyme activity beyond the test-tube levels of free enzymes in solution. These findings provide an approach for dissecting the effect of various contributors to enzyme activity and thereby provide a means for fine-tuning the entrapping matrices to optimize enzyme performance in a rational way.

Engineering productive enzyme confinement. Publishing Authors By Initials

AK Dunker,A ,

For similar technology, industry, and agriculture: manufactured materials: nanostructures research abstracts see: technology, industry, and agriculture: manufactured materials: nanostructures research

PUBMED ID PMID:

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Engineering productive enzyme confinement. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Trends in biotechnology

VOLUME: 25

Page Numbers: 189-90

Journal Abbreviation:

ISSN: 0167-7799

DAY: 26

MONTH: 03

YEAR: 2007

Engineering productive enzyme confinement. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8310903

Engineering productive enzyme confinement. Keywords Mesh Terms:

KEYWORDS: Nanostructures

MESH TERMS: chemistry

Chemical & Substance for Abstract: Engineering productive enzyme confinement. Information

Substance Name: Enzymes, Immobilized

Registry Number: 0

Grant and Affiliation Information for Engineering productive enzyme confinement.

AFFILIATION: Center for Computational Biology & Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 410 W. 10th Street, Suite 5000, Indianapolis, IN 46202, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM072614-02

ACRONYM: GM

MEDLINETA: Trends Biotechnol

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