Energy balance pathways converging on the Nhlh2 transcription factor.

Energy balance pathways converging on the Nhlh2 transcription factor. Research Abstract Details 

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Energy balance pathways converging on the Nhlh2 transcription factor. Abstract Text:

Dana L Fox,Kristen R Vella,Deborah J Good,

Multiple regulatory pathways exist to control the expression levels of neuropeptides in response to body weight and energy availability changes. Since many neuropeptides are first synthesized in a pro-neuropeptide form, the availability of processing enzymes in a neuron can control the amount of active mature neuropeptide produced at any given time. In this review, we will focus on the regulation of prohormone convertase 1 (PC1) and prohormone convertase 2 (PC2), as well as downstream neuropeptide genes. Evidence from our laboratory suggests that Nescient helix-loop-helix 2 (Nhlh2) regulates the transcription of PC1 and PC2, possibly in conjunction with the leptin-stimulated transcription factor, STAT3. Furthermore, Nhlh2 itself is a target of leptin and other energy availability signals, with high levels of expression during energy surplus, and low levels of expression in conditions of reduced energy availability such as food deprivation or cold exposure. Overall, coordinate regulation of Nhlh2, PC1, PC2 and downstream hypothalamic neuropeptides such as thyrotropin releasing hormone (TRH) and pro-opiomelanocortin (POMC) does lead to energy balance modulation and ensuing long-term changes in body weight.

Energy balance pathways converging on the Nhlh2 transcription factor. Publishing Authors By Initials

DL Fox,KR Vella,DJ Good,

For similar animals: animal population groups: organisms, genetically modified: animals, genetically modified: mice, transgenic: mice, knockout research abstracts see: animals: animal population groups: organisms, genetically modified: animals, genetically modified: mice, transgenic: mice, knockout research

PUBMED ID PMID:

MEDLINE DATE:

Energy balance pathways converging on the Nhlh2 transcription factor. Journal Published:

PUBLICATION TYPE: Review

Journal: Frontiers in bioscience : a journal and virtual li

VOLUME: 12

Page Numbers: 3983-93

Journal Abbreviation: Front. Biosci.

ISSN: 1093-4715

DAY: 1

MONTH: 05

YEAR: 2007

Energy balance pathways converging on the Nhlh2 transcription factor. Information

Number of References: 57

LANGUAGE: eng

NlmUniqueID: 9709506

Energy balance pathways converging on the Nhlh2 transcription factor. Keywords Mesh Terms:

KEYWORDS: Mice, Knockout

MESH TERMS: metabolism

Chemical & Substance for Abstract: Energy balance pathways converging on the Nhlh2 transcription factor. Information

Substance Name: Nhlh2 protein, mouse

Registry Number: 0

Grant and Affiliation Information for Energy balance pathways converging on the Nhlh2 transcription factor.

AFFILIATION: Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Corporate Research Center, Blacksburg, VA 24061, USA.

Country: United States

AGENCY: United States NIMH

GRANT: T32 MH47538

ACRONYM: MH

MEDLINETA: Front Biosci

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