Energy balance, insulin resistance biomarkers, and breast cancer risk.

Energy balance, insulin resistance biomarkers, and breast cancer risk. Research Abstract Details 

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Energy balance, insulin resistance biomarkers, and breast cancer risk. Abstract Text:

Alecia Malin Fair,Qi Dai,Xiao-Ou Shu,Charles E Matthews,Herbert Yu,Fan Jin,Yu-Tang Gao,Wei Zheng,Alecia Malin Fair,Qi Dai,Xiao-Ou Shu,Charles E Matthews,Herbert Yu,Fan Jin,Yu-Tang Gao,Wei Zheng,

BACKGROUND: American women are five times more likely to be at risk for breast cancer than women from Asian countries. Epidemiologic studies have linked energy balance to an increased risk of breast cancer, yet few studies have investigated potential mediators of this association with Chinese women. We examined the above association by blood levels of insulin-like growth factors (IGFs), binding proteins, and C-peptide in the Shanghai Breast Cancer Study (SBCS), a case-control study conducted among 1,459 breast cancer cases and 1,556 healthy Chinese women from 1996 and 1998. METHODS: In-person surveys were used to collect data on energy intake, anthropometric measures, exercise/sport activity, and occupational activity. The present analyses consisted of 397 cases and 397 controls whose blood samples were measured for levels of IGFs, insulin growth-factor binding protein 3 (IGFBP-3), C-peptide, and the relationship with physical activity status, total energy intake, and body fat distribution. RESULTS: Body mass index (BMI) and waist-to-hip ratio (WHR) were significantly positively correlated with IGFBP-3 and C-peptide. Adult exercise/sport activity was significantly negatively correlated with insulin-like growth factor 1 (IGF-I). C-peptide levels increased with increasing quartiles of WHR (p for trend<0.01). Additional analyses were performed to evaluate whether the association of energy balance measures with breast cancer risk changed after adjustment for IGFs, IGFBP-3, and C-peptide biomarkers. The associations attenuated, but none of them changed substantially. CONCLUSION: Insulin resistance biomarkers may partially explain the association between positive energy balance and breast cancer risk, but future studies are needed to identify the underlying complex biological mechanisms of action for breast cancer prevention.

Energy balance, insulin resistance biomarkers, and breast cancer risk. Publishing Authors By Initials

AM Fair,Q Dai,XO Shu,CE Matthews,H Yu,F Jin,YT Gao,W Zheng,AM Fair,Q Dai,XO Shu,CE Matthews,H Yu,F Jin,YT Gao,W Zheng,

For similar diagnosis: diagnostic techniques and procedures: physical examination: body constitution: body weights and measures: waist-hip ratio research abstracts see: diagnosis: diagnostic techniques and procedures: physical examination: body constitution: body weights and measures: waist-hip ratio research

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Energy balance, insulin resistance biomarkers, and breast cancer risk. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer detection and prevention

VOLUME: 31

Page Numbers: 214-9

Journal Abbreviation: Cancer Detect. Prev.

ISSN: 0361-090X

DAY: 23

MONTH: 07

YEAR: 2007

Energy balance, insulin resistance biomarkers, and breast cancer risk. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7704778

Energy balance, insulin resistance biomarkers, and breast cancer risk. Keywords Mesh Terms:

KEYWORDS: Waist-Hip Ratio

MESH TERMS: methods

Chemical & Substance for Abstract: Energy balance, insulin resistance biomarkers, and breast cancer risk. Information

Substance Name: Insulin-Like Growth Factor II

Registry Number: 67763-97-7

Grant and Affiliation Information for Energy balance, insulin resistance biomarkers, and breast cancer risk.

AFFILIATION: Meharry Medical College, School of Medicine, Department of Surgery, 1005 Dr. D.B. Todd Jr. Boulevard, Nashville, TN 37208-3599, USA. afair@mmc.edu

Country: England

AGENCY: United States NCI

GRANT: R01-CA64277

ACRONYM: CA

MEDLINETA: Cancer Detect Prev

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