Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats.

Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats. Research Abstract Details 

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Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats. Abstract Text:

Cendrine Godet,Jean-Michel Goujon,Isabelle Petit,Jean-Claude Lecron,Thierry Hauet, Mauco,Michel Carretier,Rene Robert,Cendrine Godet,Jean-Michel Goujon,Isabelle Petit,Jean-Claude Lecron,Thierry Hauet,Gérard Mauco,Michel Carretier,Rene Robert,

The potential implication of interleukin (IL) 6, tumor necrosis factor alpha (TNF-alpha), and IL-10 in the protective effect of low-dose lipopolysaccharide (LPS) administration against renal ischemia-reperfusion injury was evaluated in a rat model. Eighteen male Sprague-Dawley rats were injected intravenously with either 0.5 mg/kg of LPS (tolerant group) or saline (control group) 2 days before surgery. Ischemic renal injury was induced by clamping the left renal artery for 60 min on rats immediately after right-side nephrectomy. Reperfusion was obtained by clamp removal and was studied at R0 (no reperfusion), 2H (R2), and 24H (R24) by renal tubular disorder characterization and by plasma creatinine as well as renal cytokine (IL-6, IL-10, and TNF-alpha) studies. No differences were observed between the two groups as concerns the period immediately after renal ischemia (R0). The endotoxin-tolerant group was associated with a significantly lower creatinine level at R24 (231 +/- 28 vs 315 +/- 36 micromol/L; P = 0.007). Pretreatment with LPS significantly reduced the degree of proximal tubule necrosis and outer medulla congestion. In such tolerant animals, renal IL-6 production was decreased, whereas IL-10 production was significantly increased at R2 and R24. There were no differences in TNF-alpha renal production. In this study, we demonstrated that administration of low doses of LPS to rats had a protective effect from renal reperfusion injury, and our data suggest that IL-10 might play a role in this phenomenon.

Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats. Publishing Authors By Initials

C Godet,JM Goujon,I Petit,JC Lecron,T Hauet,G Mauco,M Carretier,R Robert,C Godet,JM Goujon,I Petit,JC Lecron,T Hauet,G Mauco,M Carretier,R Robert,

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Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Shock (Augusta, Ga.)

VOLUME: 25

Page Numbers: 384-8

Journal Abbreviation: Shock

ISSN: 1073-2322

DAY: 3

MONTH: Apr

YEAR: 2006

Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats. Information

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LANGUAGE: eng

NlmUniqueID: 9421564

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AFFILIATION: INSERM ERM 324, Ischémie-Reperfusion en Transplantation Rénale, EA 3806 Cytokine et Inflammation, Université de Poitiers Faculté de Médecine et de Pharmacie CHU de Poitiers, Poitiers, France.

Country: United States

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MEDLINETA: Shock

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