Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Abstract Text:

Ganesan Ramesh,Binzhi Zhang,Satoshi Uematsu,Shizuo Akira,W Brian Reeves,

A major toxicity of the cancer chemotherapeutic agent cisplatin is acute renal failure. Sepsis is a common cause of acute renal failure in humans and patients who receive cisplatin are at increased risk for sepsis. Accordingly, this study examined the interactions between cisplatin and endotoxin in vivo with respect to renal function and cytokine production. Mice were treated with either a single dose of cisplatin or two doses of LPS administered 24 h apart, or both agents in combination. Administration of 10 mg/kg cisplatin had no effect on blood urea nitrogen or creatinine levels throughout the course of the study. LPS resulted in a modest rise in blood urea nitrogen at 24 and 48 h, which returned to normal by 72 h. In contrast, mice treated with both cisplatin and LPS developed severe renal failure and an increase in mortality. Urine, but not serum, TNF-alpha levels showed a synergistic increase by cisplatin and LPS. Urinary IL-6, MCP-1, KC, and GM-CSF also showed a synergistic increase with cisplatin+LPS treatment. The renal dysfunction induced by cisplatin+LPS was completely dependent on TLR4 signaling and partially dependent on TNF-alpha production. Increased cytokine production was associated with a moderate increase in infiltrating leukocytes which was not different between cisplatin+LPS and LPS alone. These results indicate that cisplatin and LPS act synergistically to produce nephrotoxicity which may involve proinflammatory cytokine production.

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Publishing Authors By Initials

G Ramesh,B Zhang,S Uematsu,S Akira,WB Reeves,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

PUBMED ID PMID:

MEDLINE DATE:

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of physiology. Renal physiology

VOLUME: 293

Page Numbers: F325-32

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 9

MONTH: 05

YEAR: 2007

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901990

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: urine

Chemical & Substance for Abstract: Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.

AFFILIATION: Division of Nephrology, Pennsylvania State College of Medicine, 500 Univ. Dr., Hershey, PA 17033, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01-DK-063120

ACRONYM: DK

MEDLINETA: Am J Physiol Renal Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice Related Publications

• Changes in spermatogenesis and endocrine function in the ram testis due to irradiation and active immunization against luteinizing hormone-releasing hormone.
• Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells.
• Clinical effectiveness of a rehabilitation program integrating exercise, self-management, and active coping strategies for chronic knee pain: a cluster randomized trial.
• Cutaneous mastocytosis in a patient with primary Sjögren's syndrome.
• Deficiency of the type I interferon receptor protects mice from experimental lupus.
• Elevated inhibin concentration in the follicular fluid of dairy cows with chronic cystic ovarian disease.
• Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.
• Evaluation of pituitary responsiveness to LHRH as a pregnancy test in ewes.
• Further studies on pseudo-hypoparathyroidism: report of four new cases.
• Gene-specific nucleotide excision repair is impaired in human cells expressing elevated levels of high mobility group A1 nonhistone proteins.
• High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A.
• Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: A population-based study.
• Hippocampal hypocellularity in the Ts65Dn mouse originates early in development.
• In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen.
• Interpreting acne study results in a new way.
• Minimal sensor count approach to fuzzy logic rotary blood pump flow control.
• Muscle and tendon adaptations to ageing and spaceflight.
• New mouse oligodendrocyte precursor (mOP) cells for studies on oligodendrocyte maturation and function.
• Ovarian response to active immunization against luteinizing hormone in the cow.
• Pinto bean consumption changes SCFA profiles in fecal fermentations, bacterial populations of the lower bowel, and lipid profiles in blood of humans.
• Re-checking your work: the formula for success.
• Rectal erosion of synthetic mesh used in posterior colporrhaphy requiring surgical removal.
• Sodium-calcium exchange does not require allosteric calcium activation at high cytosolic sodium concentrations.
• Synchronization of estrus in yearling beef heifers with melengestrol acetate and prostaglandin F(2alpha).
• The association between culture, climate and quality of care in primary health care teams.
• The development of targeted therapies for hepatocellular cancer.
• The fight to eradicate hunger and poverty.
• The systematic monitoring of transfusion microbiology test kit performance.
• Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.
• Type I interferon as a target of treatment in SLE.