Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta.

Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta. Research Abstract Details 

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Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta. Abstract Text:

Hui-Ping Wang,Ru-Huan Mei,Xu-Yun Li,Meng-Hui Zhao,Yuan Lu,Qiang Xia,Iain Bruce,

Epidemiological data suggest that the incidence of cardiovascular disease is reduced in people who have a high intake of phytoestrogens. The plant-derived estrogen biochanin A is known to cause vasodilation, but its mechanisms of action remain unclear. This study was undertaken to investigate the effects and mechanisms of biochanin A on rat thoracic aorta. Isolated aortic rings were suspended in individual organ baths and isometric tension was measured. Biochanin A induced significant relaxation in rings with or without endothelium. Contractile responses induced by phenylephrine (PE), KCl and CaCl2were antagonized by 10^-7~10^-4mol/L biochanin A. The transient contraction elicited by PE was significantly attenuated by 10^-5mol/L biochanin A in Ca²⁺-free medium. The relaxant effect of biochanin A was significantly inhibited by pretreatment with the K⁺channel antagonists tetraethylammonium and glibenclamide in endothelium-denuded aorta. We conclude that biochanin A induces an endothelium-independent relaxation in rat aortic rings. The underlying mechanism may involve the blockage of Ca²⁺entry through both voltage-dependent and receptor-operated Ca²⁺channels, the inhibition of intracellular Ca²⁺release, and the activation of large-conductance Ca²⁺-activated K⁺channels and ATP-sensitive K⁺channels.

Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta. Publishing Authors By Initials

HP Wang,RH Mei,XY Li,MH Zhao,Y Lu,Q Xia,I Bruce,

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Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 3

Page Numbers: 2244-7

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ISSN: 1557-170X

DAY: 6

MONTH: 02

YEAR: 2005

Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta. Information

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LANGUAGE: eng

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AFFILIATION: Department of Physiology, Zhejiang University School of Medicine, Hangzhou 310031, China (phone: 0086-571-87217384; fax: 0086-571-87217146).

Country: United States

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