Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells.

Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells. Research Abstract Details 

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Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells. Abstract Text:

Craig J Hanke,Blythe B Holmes,Yafei Xu,Kasem Nithipatikom,William B Campbell,

Endothelium-derived steroidogenic factor (EDSF) is an endothelial peptide that stimulates aldosterone release from bovine adrenal zona glomerulosa (ZG) cells. The regulation of aldosterone release by combinations of EDSF and angiotensin II (AII) or EDSF and ACTH was investigated. Endothelial cells (ECs) and EC-conditioned media (ECCM) increased aldosterone release from ZG cells, an activity attributed to EDSF. AII (10(-12) to 10(-8) M) and ACTH (10(-12) to 10(-9) M) also stimulated the release of aldosterone from ZG cells. The stimulation by AII, but not ACTH, was greatly enhanced when ZG cells were coincubated with ECs. AII was metabolized by ECs to peptides identified by mass spectrometry as angiotensin (1-7) and angiotensin IV. There was very little metabolism of AII by ZG cells. Neither of these two AII metabolites altered aldosterone release from ZG cells, so they could not account for the enhanced response with ECs. AII-induced aldosterone release from ZG cells was enhanced by ECCM but not cell-free conditioned medium. This enhanced response was not due to increased EDSF release from ECs by AII. The synergistic effect of EDSF and AII was apparent when AII was added during or after the generation of ECCM and not observed when the AII component of the enhancement was blocked by the AII antagonist, losartan. These studies indicate that EDSF enhances the steroidogenic effect of AII. In the adrenal gland, ECs are in close anatomical relationship with ZG cells and may sensitize ZG cells to the steroidogenic action of AII by releasing EDSF.

Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells. Publishing Authors By Initials

CJ Hanke,BB Holmes,Y Xu,K Nithipatikom,WB Campbell,

For similar endocrine system: endocrine glands: adrenal glands: adrenal cortex: zona glomerulosa research abstracts see: endocrine system: endocrine glands: adrenal glands: adrenal cortex: zona glomerulosa research

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Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Endocrinology

VOLUME: 148

Page Numbers: 317-23

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 19

MONTH: 10

YEAR: 2006

Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells. Keywords Mesh Terms:

KEYWORDS: Zona Glomerulosa

MESH TERMS: metabolism

Chemical & Substance for Abstract: Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells. Information

Substance Name: Angiotensin I

Registry Number: 9041-90-1

Grant and Affiliation Information for Endothelium-derived steroidogenic factor enhances angiotensin II-stimulated aldosterone release by bovine zona glomerulosa cells.

AFFILIATION: Department of Human Biology, University of Wisconsin-Green Bay, Wisconsin 54301, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR-17824

ACRONYM: RR

MEDLINETA: Endocrinology

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