Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model.

Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. Research Abstract Details 

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Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. Abstract Text:

Roman J Garcia,Avner Ittah,Sheyla Mirabal,Jessica Figueroa,Lidice Lopez,Adam B Glick,Lidia Kos,Roman J Garcia,Avner Ittah,Sheyla Mirabal,Jessica Figueroa,Lidice Lopez,Adam B Glick,Lidia Kos,

Endothelin 3 (Edn3) encodes a ligand important to developing neural crest cells and is allelic to the spontaneous mouse mutation occurring at the lethal spotting (ls) locus. Edn3(ls/ls) mutants exhibit a spotted phenotype due to reduced numbers of neural crest-derived melanocyte precursors in the skin. In this study, we show that when Edn3 is driven by the keratin 5 promoter and thereby placed proximal to melanocyte lineage cells, adult mice manifest pigmented skin harboring dermal melanocytes. Using a tetracycline inducible system, we show that the postnatal expression of Edn3 is required to maintain these dermal melanocytes, and that early expression of the Edn3 transgene is important to the onset of the hyperpigmentation phenotype. Crosses into Edn3(ls/ls) mutants demonstrate that the Edn3 transgene expression does not fully compensate for the endogenous expression pattern. Crosses into tyrosine kinase receptor Kit(Wv) mutants indicate that Edn3 can partially compensate for Kit's role in early development. Crosses into A(y) mutant mice considerably darkened their yellow coat color suggesting a previously unreported role for endothelin signaling in pigment switching. These results demonstrate that exogenous Edn3 affects both precursors and differentiated melanocytes, leading to a phenotype with characteristics similar to the human skin condition dermal melanocytosis.

Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. Publishing Authors By Initials

RJ Garcia,A Ittah,S Mirabal,J Figueroa,L Lopez,AB Glick,L Kos,RJ Garcia,A Ittah,S Mirabal,J Figueroa,L Lopez,AB Glick,L Kos,

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Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of investigative dermatology

VOLUME: 128

Page Numbers: 131-42

Journal Abbreviation: J. Invest. Dermatol.

ISSN: 1523-1747

DAY: 5

MONTH: 07

YEAR: 2007

Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model. Information

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LANGUAGE: eng

NlmUniqueID: 426720

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Grant and Affiliation Information for Endothelin 3 induces skin pigmentation in a keratin-driven inducible mouse model.

AFFILIATION: Department of Biological Sciences, Florida International University, Miami, Florida 33199, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T34 GM008771

ACRONYM: GM

MEDLINETA: J Invest Dermatol

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