Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1.

Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Research Abstract Details 

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Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Abstract Text:

Toru Yukami,Minoru Hasegawa,Yukiyo Matsushita,Tomoyuki Fujita,Takashi Matsushita,Mayuka Horikawa,Kazuhiro Komura,Koichi Yanaba,Yasuhito Hamaguchi,Tetsuya Nagaoka,Fumihide Ogawa,Manabu Fujimoto,Douglas A Steeber,Thomas F Tedder,Kazuhiko Takehara,Shinichi Sato,

Skin wound healing is mediated by inflammatory cell infiltration that is highly regulated by various adhesion molecules. Mice lacking intercellular adhesion molecule-1 (ICAM-1) delayed skin wound healing and mice lacking both L-selectin and ICAM-1 (L-selectin/ICAM-1(-/-)) show more delayed wound healing. Deficiency of both endothelial selectins (E-selectin or P-selectin) also delays wound healing. However, the relative contribution and interaction of selectins and ICAM-1 to the wound healing remain unknown. To clarify them, repair of excisional wounds was examined in L-selectin/ICAM-1(-/-) mice, wild-type mice with both E- and P-selectin blockade, and L-selectin/ICAM-1(-/-) mice with both E- and P-selectin blockade. Wild-type mice with both E- and P-selectin blockade showed delayed wound healing that was comparable with that in L-selectin/ICAM-1(-/-) mice. Combined E- and P-selectin blockade in L-selectin/ICAM-1(-/-) mice resulted in more significant delay. Mice lacking or blocked for adhesion molecules also showed suppressed keratinocyte migration, angiogenesis, granulation tissue formation, leukocyte infiltration, and cytokine expression, including transforming growth factor-beta and interleukin-6. Application of basic fibroblast growth factor (bFGF) but not platelet-derived growth factor to the wounds significantly improved wound healing in L-selectin/ICAM-1(-/-) mice with both E- and P-selectin blockade. bFGF significantly increased the leukocyte infiltration and subsequent fibrogenic cytokine production, as well as keratinocyte migration, angiogenesis, and collagen synthesis despite the loss of four kinds of adhesion molecules. These results indicate that skin wound healing is regulated cooperatively by all selectins and ICAM-1 and may provide critical information for the therapy of skin wounds.

Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Publishing Authors By Initials

T Yukami,M Hasegawa,Y Matsushita,T Fujita,T Matsushita,M Horikawa,K Komura,K Yanaba,Y Hamaguchi,T Nagaoka,F Ogawa,M Fujimoto,DA Steeber,TF Tedder,K Takehara,S Sato,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of leukocyte biology

VOLUME: 82

Page Numbers: 519-31

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 26

MONTH: 06

YEAR: 2007

Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8405628

Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: physiology

Chemical & Substance for Abstract: Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1.

AFFILIATION: Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13-1, Takara-machi, Kanazawa 920-8641, Japan.

Country: United States

AGENCY: United States NCI

GRANT: CA81776

ACRONYM: CA

MEDLINETA: J Leukoc Biol

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