Endothelial NO/cGMP-Dependent Vascular Relaxation of Cornuside Isolated from the Fruit of Cornus officinalis.

Endothelial NO/cGMP-Dependent Vascular Relaxation of Cornuside Isolated from the Fruit of Cornus officinalis. Research Abstract Details 

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Endothelial NO/cGMP-Dependent Vascular Relaxation of Cornuside Isolated from the Fruit of Cornus officinalis. Abstract Text:

Dae Gill Kang,Deok Ho Choi,Jun Kyoung Lee,Yun Jeong Lee,Mi Kyoung Moon,Sun Nye Yang,Tae Oh Kwon,Ji Woong Kwon,Jin Sook Kim,Ho Sub Lee,Dae Gill Kang,Deok Ho Choi,Jun Kyoung Lee,Yun Jeong Lee,Mi Kyoung Moon,Sun Nye Yang,Tae Oh Kwon,Ji Woong Kwon,Jin Sook Kim,Ho Sub Lee,

Cornuside is a bisiridoid glucoside compound isolated from the fruit of CORNUS OFFICINALIS Sieb. et Zucc. (Cornaceae). In the present study, we investigated the effect of cornuside on vascular tone in rat aortic tissue. Cornuside induced a concentration-dependent relaxation of the phenylephrine-precontracted rat aorta, which was abolished by removal of the endothelial layer. Pretreatment of the aortic tissues with either N(G)-nitro- L-arginine methyl ester (L-NAME) or 1 H- -oxadiazole-[4,3-alpha]-quinoxalin-1-one (ODQ) completely inhibited the relaxation induced by cornuside. However, the relaxant effect of cornuside was not blocked by pretreatment with verapamil, diltiazem, tetraethylammonium (TEA), glibenclamide, indomethacin, atropine, or propranolol. In addition, incubation of human umbilical vein endothelial cells (HUVECs) with cornuside increased the production of cGMP in a dose-dependent manner, but this effect was blocked by pretreatment with L-NAME and ODQ, respectively. Taken together, the present study suggests that cornuside dilates vascular smooth muscle via endothelium-dependent nitric oxide (NO)/cGMP signaling. ATP:adenosine triphosphate cGMP:guanosine 3',5'-cyclic monophosphate DMSO:dimethyl sulfoxide EDHF:endothelium-derived hyperpolarizing factor EDRF:endothelium-derived relaxing factor EDTA:ethylenediaminetetraacetic acid FBS:fetal bovine serum HUVECs:human umbilical vein endothelial cells IBMX:3-isobutyl-1-methylxanthine L-NAME: N(G)-nitro- L-arginine methyl ester NO:nitric oxide ODQ:1 H- -oxadiazole-[4,3-alpha]-quinoxalin-1-one RIA:radioimmunoassay TEA: tetraethylammonium.

Endothelial NO/cGMP-Dependent Vascular Relaxation of Cornuside Isolated from the Fruit of Cornus officinalis. Publishing Authors By Initials

DG Kang,DH Choi,JK Lee,YJ Lee,MK Moon,SN Yang,TO Kwon,JW Kwon,JS Kim,HS Lee,DG Kang,DH Choi,JK Lee,YJ Lee,MK Moon,SN Yang,TO Kwon,JW Kwon,JS Kim,HS Lee,

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Endothelial NO/cGMP-Dependent Vascular Relaxation of Cornuside Isolated from the Fruit of Cornus officinalis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Planta medica

VOLUME: 73

Page Numbers: 1436-40

Journal Abbreviation: Planta Med.

ISSN: 0032-0943

DAY: 10

MONTH: 10

YEAR: 2007

Endothelial NO/cGMP-Dependent Vascular Relaxation of Cornuside Isolated from the Fruit of Cornus officinalis. Information

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LANGUAGE: eng

NlmUniqueID: 66751

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AFFILIATION: Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, Republic of Korea.

Country: Germany

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MEDLINETA: Planta Med

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