Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen.

Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Research Abstract Details 

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Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Abstract Text:

J A Buras,W R Reenstra,

Ischemia/reperfusion injury plays a central role in the development of tissue injury during multiple central nervous system diseases including acute stroke. Neutrophil adhesion to the endothelium indicates a major component of ischemia/reperfusion pathophysiology, and may be a target for therapeutic intervention. Hyperbaric oxygen has been documented to reduce ischemia/reperfusion injury in a number of different experimental models and in a single human randomized clinical trial. One mechanism responsible for the beneficial effect of hyperbaric oxygen in treatment of ischemia/reperfusion injury involves suppression of neutrophil-endothelial adhesion. This review intends to describe the current basic mechanisms responsible for hyperbaric oxygen-mediated inhibition of neutrophil-endothelial interactions following ischemia/reperfusion injury.

Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Publishing Authors By Initials

JA Buras,WR Reenstra,

For similar cardiovascular diseases: vascular diseases: reperfusion injury research abstracts see: cardiovascular diseases: vascular diseases: reperfusion injury research

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Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Journal Published:

PUBLICATION TYPE: Review

Journal: Neurological research

VOLUME: 29

Page Numbers: 127-31

Journal Abbreviation:

ISSN: 0161-6412

DAY: 3

MONTH: Mar

YEAR: 2007

Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Information

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LANGUAGE: eng

NlmUniqueID: 7905298

Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Keywords Mesh Terms:

KEYWORDS: Reperfusion Injury

MESH TERMS: therapy

Chemical & Substance for Abstract: Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen. Information

Substance Name: Nitric Oxide

Registry Number: 10102-43-9

Grant and Affiliation Information for Endothelial-neutrophil interactions during ischemia and reperfusion injury: basic mechanisms of hyperbaric oxygen.

AFFILIATION: Department of Biology and Department of Pharmaceutical Sciences, New England Inflammation and Tissue Protection Institute at Northeastern University, Boston, MA 02115, USA. jburas@mac.com

Country: England

AGENCY: United States NIAID

GRANT: AI062689

ACRONYM: AI

MEDLINETA: Neurol Res

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