Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells.

Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells. Research Abstract Details 

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Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells. Abstract Text:

Yasuteru Sano,Fumitaka Shimizu,Hiroto Nakayama,Masaaki Abe,Toshihiko Maeda,Sumio Ohtsuki,Tetsuya Terasaki,Masuo Obinata,Masatsugu Ueda,Ri-ichi Takahashi,Takashi Kanda,Yasuteru Sano,Fumitaka Shimizu,Hiroto Nakayama,Masaaki Abe,Toshihiko Maeda,Sumio Ohtsuki,Tetsuya Terasaki,Masuo Obinata,Masatsugu Ueda,Ri-ichi Takahashi,Takashi Kanda,Yasuteru Sano,Fumitaka Shimizu,Hiroto Nakayama,Masaaki Abe,Toshihiko Maeda,Sumio Ohtsuki,Tetsuya Terasaki,Masuo Obinata,Masatsugu Ueda,Ri-ichi Takahashi,Takashi Kanda,

In autoimmune disorders of the peripheral nervous system (PNS) such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy, breakdown of the blood-nerve barrier (BNB) has been considered as a key step in the disease process. Hence, it is important to know the cellular property of peripheral nerve microvascular endothelial cells (PnMECs) constituting the bulk of BNB. Although many in vitro models of the blood-brain barrier (BBB) have been established, very few in vitro BNB models have been reported so far. We isolated PnMECs from transgenic rats harboring the temperature-sensitive SV40 large T-antigen gene (tsA58 rat) and investigated the properties of these "barrier-forming cells". Isolated PnMECs (TR-BNBs) showed high transendothelial electrical resistance and expressed tight junction components and various types of influx as well as efflux transporters that have been reported to function at BBB. Furthermore, we confirmed the in vivo expression of various BBB-forming endothelial cell markers in the endoneurium of a rat sciatic nerve. These results suggest that PnMECs constituting the bulk of BNB have a highly specialized characteristic resembling the endothelial cells forming BBB.

Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells. Publishing Authors By Initials

Y Sano,F Shimizu,H Nakayama,M Abe,T Maeda,S Ohtsuki,T Terasaki,M Obinata,M Ueda,R Takahashi,T Kanda,Y Sano,F Shimizu,H Nakayama,M Abe,T Maeda,S Ohtsuki,T Terasaki,M Obinata,M Ueda,R Takahashi,T Kanda,Y Sano,F Shimizu,H Nakayama,M Abe,T Maeda,S Ohtsuki,T Terasaki,M Obinata,M Ueda,R Takahashi,T Kanda,

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Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell structure and function

VOLUME: 32

Page Numbers: 139-47

Journal Abbreviation: Cell Struct. Funct.

ISSN: 1347-3700

DAY: 5

MONTH: 12

YEAR: 2007

Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells. Information

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LANGUAGE: eng

NlmUniqueID: 7608465

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AFFILIATION: Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine.

Country: Japan

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MEDLINETA: Cell Struct Funct

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