Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord.

Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Research Abstract Details 

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Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Abstract Text:

Gizelda T B Casella,Mary Bartlett Bunge,Patrick M Wood,

Contusion of the spinal cord causes an immediate local loss of neurons and disruption of vasculature; additional loss continues thereafter. To explore the possibility of a causal link between delayed endothelial cell (EC) death and secondary neural cell loss, we evaluated neural and endothelial cell survival, and measured inflammatory cell infiltration, at times up to 48 h after contusion injury to the adult rat thoracic spinal cord. Female Fischer rats (200 g), subjected to moderate (10 g x 12.5 mm) weight drop injuries by the MASCIS (NYU) impactor, were analyzed at 15 min and at 1, 8, 24 and 48 h. ECs, neurons, astrocytes, oligodendrocytes, neutrophils and activated macrophages/microglia were counted in transverse sections. At the injury site, 90% of all neurons died within 48 h of injury; no medium-large diameter neurons survived beyond 48 h. EC death occurred with kinetics similar to glial cell death. Because, in the injury site, most cell death occurred before 8 h, it preceded inflammatory cell infiltration. Three millimeters rostral and caudal to the injury epicenter neuronal numbers were stable for 8 h, and a sharp decrease in neuronal numbers beginning at 8 h strongly correlated with the onset of inflammatory cell infiltration. Glial and blood vessel numbers remained relatively stable in these areas up to 48 h. These results suggest that the loss of ECs during the first 48 h after a contusion injury is not a major cause of neuronal and glial cell death and, in tissue adjacent to the epicenter, inflammatory cell infiltration leads to neuronal loss.

Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Publishing Authors By Initials

GT Casella,MB Bunge,PM Wood,

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Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental neurology

VOLUME: 202

Page Numbers: 8-20

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ISSN: 0014-4886

DAY: 26

MONTH: 07

YEAR: 2006

Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord.

AFFILIATION: The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33136, USA.

Country: United States

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MEDLINETA: Exp Neurol

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