Endothelial cell loss after photorefractive keratectomy for myopia.

Endothelial cell loss after photorefractive keratectomy for myopia. Research Abstract Details 

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Endothelial cell loss after photorefractive keratectomy for myopia. Abstract Text:

PURPOSE: To study the long-term effect of 193 nm excimer laser photorefractive keratectomy (PRK) on the human corneal endothelial cell density. SUBJECTS AND METHODS: One hundred and twenty-four eyes from 71 patients underwent photorefractive keratectomy for myopia or myopic-astigmatism. Endothelial cell density was examined a short time before the operation and on an average of 50 months after the operation using a contact specular microscope. A subgroup of 32 eyes from 20 patients treated only once was examined preoperatively and 7 and 52 months postoperatively. The endothelial cell densities were corrected for the changing magnification of the contact specular microscope with changing central corneal thickness and for the expected physiological cell loss with time. RESULTS: The average endothelial cell density was preoperatively 3098+/-283 cells/mm2 (mean+/-SD) and postoperatively 3048+/-294 cells/mm2 corresponding to a change of -50+/-157 cells/mm2. This was statistically significantly different from zero in a paired t-test (n=124, t=3.58, 2p<0.001). The average changes in endothelial cell density for the subgroup were -34+/-159 cells/mm2 for the postoperative time interval 0-7 months and -20+/-188 cells/mm2 for the postoperative time interval 7-52 months. These results were not statistically significantly different from zero in a paired t-test (n=32, t=1.21 and t=0.60, 2p>0.05). A statistically significant negative correlation between preoperative cell density and the change in cell density was found (n=124, r=-0.21, 2p<0.05). CONCLUSION: This study suggests a potentially harmful effect of PRK on the human corneal endothelium. It appears that most cells are lost during ablation or within the first period of time after PRK.

Endothelial cell loss after photorefractive keratectomy for myopia. Publishing Authors By Initials

For similar surgical procedures, operative: reoperation research abstracts see: surgical procedures, operative: reoperation research

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Endothelial cell loss after photorefractive keratectomy for myopia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta ophthalmologica Scandinavica

VOLUME: 76

Page Numbers: 304-7

Journal Abbreviation: Acta Ophthalmol Scand

ISSN: 1395-3907

DAY: 17

MONTH: Jun

YEAR: 1998

Endothelial cell loss after photorefractive keratectomy for myopia. Information

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LANGUAGE: eng

NlmUniqueID: 9507578

Endothelial cell loss after photorefractive keratectomy for myopia. Keywords Mesh Terms:

KEYWORDS: Reoperation

MESH TERMS: adverse effects

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Grant and Affiliation Information for Endothelial cell loss after photorefractive keratectomy for myopia.

AFFILIATION: Department of Ophthalmology, Arhus University Hospital, Denmark.

Country: DENMARK

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MEDLINETA: Acta Ophthalmol Scand

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