Endoscopic deployment of multiple JOSTENT SelfX is effective and safe in treatment of malignant hilar biliary strictures.

Endoscopic deployment of multiple JOSTENT SelfX is effective and safe in treatment of malignant hilar biliary strictures. Research Abstract Details 

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Endoscopic deployment of multiple JOSTENT SelfX is effective and safe in treatment of malignant hilar biliary strictures. Abstract Text:

Hirofumi Kawamoto,Koichiro Tsutsumi,Ryo Harada,Masakuni Fujii,Hironari Kato,Ken Hirao,Naoko Kurihara,Takashi Nakanishi,Osamu Mizuno,Etsuji Ishida,Tsuneyoshi Ogawa,Hirotoshi Fukatsu,Kohsaku Sakaguchi,

BACKGROUND & AIMS: For the treatment of unresectable biliary tract carcinoma with hilar biliary stricture, antitumor therapy and biliary stenting should be addressed in terms of prolonged survival with a good quality of life. However, the endoscopic management of malignant hilar biliary strictures is difficult even for an expert endoscopist. We evaluated the efficacy and safety of the endoscopic deployment of multiple JOSTENT SelfX units in patients with hilar biliary strictures treated with or without chemotherapy. METHODS: Between November 2003 and December 2006, endoscopic deployment of multiple JOSTENT SelfX units in hilar biliary strictures by using a partial stent-in-stent procedure was performed on 41 consecutive patients with primary cholangiocarcinoma (n = 34) and gallbladder carcinoma (n = 7) at a gastroenterologic center of Okayama University Hospital. Thirty-three patients were treated with gemcitabine (n = 25) or S-1 (n = 8). RESULTS: Metallic stent deployment was successfully accomplished in all cases via only endoscopic procedures. During the follow-up period (mean, 210 days), mean patency time was 150 days, and metallic stent obstruction occurred in 15 cases (37%). Although a repeat intervention was required in all metallic stent obstructed cases, the deployment of the second metallic or plastic stent was completed successfully. The remaining 26 cases (63%) required no interventions. The median overall survival period was only 235 days. However, that of the patients receiving chemotherapy was 392 days. CONCLUSIONS: Endoscopic partial stent-in-stent deployment with multiple JOSTENT SelfX prostheses is effective and safe for the treatment of malignant hilar biliary stricture even in patients receiving chemotherapy.

Endoscopic deployment of multiple JOSTENT SelfX is effective and safe in treatment of malignant hilar biliary strictures. Publishing Authors By Initials

H Kawamoto,K Tsutsumi,R Harada,M Fujii,H Kato,K Hirao,N Kurihara,T Nakanishi,O Mizuno,E Ishida,T Ogawa,H Fukatsu,K Sakaguchi,

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Endoscopic deployment of multiple JOSTENT SelfX is effective and safe in treatment of malignant hilar biliary strictures. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical gastroenterology and hepatology : the off

VOLUME: 6

Page Numbers: 401-8

Journal Abbreviation: Clin. Gastroenterol. Hepatol.

ISSN: 1542-7714

DAY: 7

MONTH: 03

YEAR: 2008

Endoscopic deployment of multiple JOSTENT SelfX is effective and safe in treatment of malignant hilar biliary strictures. Information

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LANGUAGE: eng

NlmUniqueID: 101160775

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AFFILIATION: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Science, Okayama City, Japan. h-kawamo@md.okayama-u.ac.jp

Country: United States

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MEDLINETA: Clin Gastroenterol Hepatol

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