Endogenous sex hormones and glucose tolerance status in postmenopausal women.

Endogenous sex hormones and glucose tolerance status in postmenopausal women. Research Abstract Details 

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Endogenous sex hormones and glucose tolerance status in postmenopausal women. Abstract Text:

Sherita Hill Golden,Adrian S Dobs,Dhananjay Vaidya,Moyses Szklo,Susan Gapstur,Peter Kopp,Kiang Liu,Pamela Ouyang,

CONTEXT: In postmenopausal women, endogenous estradiol (E2) and free testosterone (T) have been positively associated with glucose intolerance and type 2 diabetes. Most studies have not examined these associations in a large group of postmenopausal women. OBJECTIVE: The objective was to examine the association between endogenous sex hormones and glucose tolerance in postmenopausal women. DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional study of 1973 postmenopausal women ages 45-84 yr, not taking hormone replacement therapy, in the Multi-Ethnic Study of Atherosclerosis baseline examination. MAIN OUTCOME MEASURES: Impaired fasting glucose (IFG) and diabetes were defined based on fasting blood sugar and/or treatment for diabetes. In women with normal glucose tolerance, insulin resistance was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Increasing quartiles of bioavailable T and E2 and decreasing quartiles of SHBG were associated with significantly increased odds of IFG and diabetes (all P for trend<0.001). Except for the association of bioavailable T with diabetes, the other associations persisted after multivariable adjustment. Although higher dehydroepiandrostenedione (DHEA) was associated with greater odds of IFG (P for trend=0.02), it was not associated with diabetes. Of 1100 women with normal glucose tolerance, E2 and DHEA were positively associated, and SHBG was inversely associated with HOMA-IR (all P<0.001) after multivariable adjustment. Bioavailable T was associated with HOMA-IR (P<0.001), but not fasting glucose. CONCLUSION: Of postmenopausal women, endogenous bioavailable T, E2, and DHEA were positively associated and SHBG was negatively associated with insulin resistance.

Endogenous sex hormones and glucose tolerance status in postmenopausal women. Publishing Authors By Initials

SH Golden,AS Dobs,D Vaidya,M Szklo,S Gapstur,P Kopp,K Liu,P Ouyang,

For similar polycyclic compounds: steroids: androstanes: androstenes: androstenols: testosterone research abstracts see: polycyclic compounds: steroids: androstanes: androstenes: androstenols: testosterone research

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Endogenous sex hormones and glucose tolerance status in postmenopausal women. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 1289-95

Journal Abbreviation:

ISSN: 0021-972X

DAY: 23

MONTH: 01

YEAR: 2007

Endogenous sex hormones and glucose tolerance status in postmenopausal women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

Endogenous sex hormones and glucose tolerance status in postmenopausal women. Keywords Mesh Terms:

KEYWORDS: Testosterone

MESH TERMS: blood

Chemical & Substance for Abstract: Endogenous sex hormones and glucose tolerance status in postmenopausal women. Information

Substance Name: Testosterone

Registry Number: 58-22-0

Grant and Affiliation Information for Endogenous sex hormones and glucose tolerance status in postmenopausal women.

AFFILIATION: Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. sahill@jhmi.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL074406

ACRONYM: HL

MEDLINETA: J Clin Endocrinol Metab

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