Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.

Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. Research Abstract Details 

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Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. Abstract Text:

M Crumeyrolle-Arias,A Medvedev,A Cardona,M C Tournaire,V Glover,M Crumeyrolle-Arias,A Medvedev,A Cardona,M C Tournaire,V Glover,

Isatin is an endogenous oxidized indole that influences a range of processes in vivo and in vitro. It has a distinct and discontinuous distribution in the brain and [3H]isatin binding sites are widely distributed in rat brain sections. The highest labelling is found in hypothalamic nuclei and in the cortex, hippocampus, and cerebellum (Crumeyrolle-Arias et al., 2003). However, the properties of most isatin binding sites and their physiological ligands remain unknown. In the present study the effects of three endogenous oxidized indoles (oxindole, 5-hyxdoxyoxindole, and isatin) on [3H]isatin binding were investigated in rat brain sections. In most regions cold isatin (0.2 mM) significantly reduced [3H]isatin binding. In addition to isatin, the other endogenous oxidized indoles, 5-hydroxyoxindole and oxindole were effective in displacing [3H]isatin. Total irreversible inhibition of monoamine oxidases caused inhibition of specific [3H]isatin binding in 7 of 10 brain region studied. This was accompanied by altered sensitivity of [3H]isatin binding to these indoles, including regions where a decrease of specific binding was not detected. The combinations of the three oxidized indoles produced two clear effects: augmentation (potentiation) and attenuation (blockade) of inhibitory activity compared with the independent effects of these compounds. The different effects of oxidized indoles and their combinations (isatin + 5-hydroxyoxindole and isatin + oxindole) in various brain regions therefore suggest an interaction of [(3H]isatin with different and multiple isatin-binding sites, which exhibit different sensitivity to endogenous oxidizing indoles.

Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. Publishing Authors By Initials

M Crumeyrolle-Arias,A Medvedev,A Cardona,MC Tournaire,V Glover,M Crumeyrolle-Arias,A Medvedev,A Cardona,MC Tournaire,V Glover,

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Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neural transmission. Supplementum

VOLUME:

Page Numbers: 29-34

Journal Abbreviation: J. Neural Transm. Suppl.

ISSN: 0303-6995

DAY: 6

MONTH: 11

YEAR: 2007

Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.

AFFILIATION: INSERM U513, UFR Médecine, Université Paris 12, Créteil, France. Michele.Crumeyrolle@creteil.inserm.fr

Country: Austria

AGENCY: United Kingdom Wellcome T

GRANT: 072381

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MEDLINETA: J Neural Transm Suppl

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