Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors.

Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors. Research Abstract Details 

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Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors. Abstract Text:

Recent empirical data have elucidated a compelling physiological basis for endogenously expressed, chemically authentic, morphine and its cognate mu3 and mu4 opiate receptors. Cellular "morphinergic" signaling is predominantly targeted to autocrine/paracrine regulatory processes and is reciprocally linked to stimulated production and release of the free radical gas nitric oxide (NO). Additionally, we have recently described a functionally coupled mu4 opiate receptor/NO regulatory pathway in human multi-lineage progenitor cells in the absence of traditional opioid, neuropeptide, or catecholamine G-protein coupled receptors (GPCRs). These accumulated data not only suggest an evolutionary primacy for morphinergic signaling as a fundamental regulatory mechanism, but identify mu3 and mu4 opiate receptors as candidate primordial GPCRs that may have served as prototypic models for diverse families of GPCRs. The present review focuses on the parallel roles of morphinergic signaling and endogenous opioid peptide-mediated regulatory processes in immune function and the development of defensive integrated behaviors including nociception from rudimentary cellular responses to chemical/environmental challenges. Finally, structural similarities between the intracellular domains of mu3 opiate receptors and chemokine receptors CCR2 and CCR5 provide an additional chemical basis for these contentions.

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Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Seminars in cancer biology

VOLUME: 18

Page Numbers: 190-8

Journal Abbreviation: Semin. Cancer Biol.

ISSN: 1096-3650

DAY: 5

MONTH: 12

YEAR: 2007

Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors. Information

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LANGUAGE: eng

NlmUniqueID: 9010218

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Grant and Affiliation Information for Endogenous opiates, opioids, and immune function: evolutionary brokerage of defensive behaviors.

AFFILIATION: Neuroscience Research Institute, State university of New York, College at Old Westbury, Old Westbury, NY 11568, USA. gstefano@sunynri.org

Country: England

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MEDLINETA: Semin Cancer Biol

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