Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma.

Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Research Abstract Details 

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Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Abstract Text:

Giovana R Thomas,Judy Wen,

BACKGROUND: Most tumor tissues, especially those of non-hematopoietic origin, do not express CD80 co-stimulatory molecules, possibly as a mechanism to evade immune surveillance. The objective of this study was to determine whether abundant endogenous CD80 expression on oral squamous cell carcinoma (SCC) early during tumor progression can facilitate immune elimination and reverse immune tolerance. MATERIALS AND METHODS: The growth of regressor and progressor oral SCC lines with differing endogenous CD80 expression were examined in immune-competent and -deficient mice. Immune effectors were determined by T-cell depletion experiments and immunohistochemistry. RESULTS: Our studies show regression of early tumor growth when immunocompetent animals are inoculated with oral SCC progressor cell lines expressing abundant endogenous CD80. The CD80-induced antitumor response was due largely to induced T-cell responses. CONCLUSION: Our findings suggest that inadequate CD80 expression during early oral SCC formation may contribute to the escape of tumors from immune elimination. This information can be useful in the design of new approaches to generate more effective immunotherapy against this disease.

Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Publishing Authors By Initials

GR Thomas,J Wen,

For similar neoplasms: neoplasms by site: head and neck neoplasms: mouth neoplasms research abstracts see: neoplasms: neoplasms by site: head and neck neoplasms: mouth neoplasms research

PUBMED ID PMID:

MEDLINE DATE: 2006 Nov-Dec

Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Anticancer research

VOLUME: 26

Page Numbers: 4093-101

Journal Abbreviation: Anticancer Res.

ISSN: 0250-7005

DAY: 3

MONTH: 12

YEAR: 2007

Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102988

Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Keywords Mesh Terms:

KEYWORDS: Mouth Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma. Information

Substance Name: Antigens, CD80

Registry Number: 0

Grant and Affiliation Information for Endogenous expression of CD80 co-stimulatory molecule facilitates in vivo tumor regression of oral squamous carcinoma.

AFFILIATION: University of Miami Miller School of Medicine/Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA. gthomas@med.miami.edu

Country: Greece

AGENCY: United States NIDCR

GRANT: DE015338A

ACRONYM: DE

MEDLINETA: Anticancer Res

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