Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery.

Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Research Abstract Details 

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Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Abstract Text:

Andreas ,Christoph Schnurr,Atsunori Nakao,Sandra ,Beverley A Moore,Noriko Murase, Kalff,Anthony J Bauer,

OBJECTIVE: To investigate muscularis inflammation and endogenous endotoxin as causes of postoperative ileus. BACKGROUND: Postoperative inflammatory ileus of the colon is associated with a significant delay in gastrointestinal transit. We investigated whether these changes are caused by the downstream obstructive barrier of the surgically altered colon or by small intestinal muscularis inflammation itself. Furthermore, we evaluated the mechanistic role of gut derived endotoxin in the development of postoperative intestinal dysfunction. METHODS: Rats underwent surgical manipulation of the colon. Isolated gastrointestinal transit was analyzed in animals with ileostomy. The perioperative emigration of intracolonic particles was investigated by colonic luminal injection of fluorescently labeled LPS and microspheres. Mediator mRNA induction was quantified by real-time RT-PCR. Muscularis leukocytic infiltrates were characterized. In vitro circular muscle contractility was assessed in a standard organ bath. RESULTS: Ileostomy rats presented with a significant delay in small intestinal transit after colonic manipulation. This was associated with leukocyte recruitment and inflammatory mediator mRNA induction within the small intestinal muscularis. Colonic manipulation caused the transference of intracolonic LPS and microspheres into the intestinal muscularis. Postoperative in vitro small intestinal circular muscle contractility was impaired by 42% compared with controls. Gut decontamination and TLR-4 deletion significantly alleviated the small intestinal muscularis inflammation and prevented intestinal muscle dysfunction. CONCLUSIONS: Selective colonic manipulation initiates a distant inflammatory response in the small intestinal muscularis that contributes to postoperative ileus. The data provide evidence that gut-derived bacterial products are mechanistically involved in the initiation of this remote inflammatory cascade.

Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Publishing Authors By Initials

A ,C Schnurr,A Nakao,S ,BA Moore,N Murase,JC Kalff,AJ Bauer,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, neurological: neurologic examination: reflex research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, neurological: neurologic examination: reflex research

PUBMED ID PMID:

MEDLINE DATE:

Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of surgery

VOLUME: 245

Page Numbers: 734-44

Journal Abbreviation:

ISSN: 0003-4932

DAY: 3

MONTH: May

YEAR: 2007

Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372354

Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Keywords Mesh Terms:

KEYWORDS: Reflex

MESH TERMS: physiology

Chemical & Substance for Abstract: Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery. Information

Substance Name: Inflammation Mediators

Registry Number: 0

Grant and Affiliation Information for Endogenous endotoxin participates in causing a panenteric inflammatory ileus after colonic surgery.

AFFILIATION: Department of Medicine, Division of Gastroenterology, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM 58241

ACRONYM: GM

MEDLINETA: Ann Surg

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