Endodermal Nodal-related signals and mesoderm induction in Xenopus.

Endodermal Nodal-related signals and mesoderm induction in Xenopus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Endodermal Nodal-related signals and mesoderm induction in Xenopus. Abstract Text:

In Xenopus, mesoderm induction by endoderm at the blastula stage is well documented, but the molecular nature of the endogenous inductive signals remains unknown. The carboxy-terminal fragment of Cerberus, designated Cer-S, provides a specific secreted antagonist of mesoderm-inducing Xenopus Nodal-Related (Xnr) factors. Cer-S does not inhibit signalling by other mesoderm inducers such as Activin, Derrière, Vg1 and BMP4, nor by the neural inducer Xnr3. In the present study we show that Cer-S blocks the induction of both dorsal and ventral mesoderm in animal-vegetal Nieuwkoop-type recombinants. During blastula stages Xnr1, Xnr2 and Xnr4 are expressed in a dorsal to ventral gradient in endodermal cells. Dose-response experiments using cer-S mRNA injections support the existence of an endogenous activity gradient of Xnrs. Xnr expression at blastula can be activated by the vegetal determinants VegT and Vg1 acting in synergy with dorsal (beta)-catenin. The data support a modified model for mesoderm induction in Xenopus, in which mesoderm induction is mediated by a gradient of multiple Nodal-related signals released by endoderm at the blastula stage.

Endodermal Nodal-related signals and mesoderm induction in Xenopus. Publishing Authors By Initials

For similar proteins: amphibian proteins: xenopus proteins research abstracts see: proteins: amphibian proteins: xenopus proteins research

PUBMED ID PMID:

MEDLINE DATE:

Endodermal Nodal-related signals and mesoderm induction in Xenopus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Development (Cambridge, England)

VOLUME: 127

Page Numbers: 1173-83

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 19

MONTH: Mar

YEAR: 2000

Endodermal Nodal-related signals and mesoderm induction in Xenopus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701744

Endodermal Nodal-related signals and mesoderm induction in Xenopus. Keywords Mesh Terms:

KEYWORDS: Xenopus Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Endodermal Nodal-related signals and mesoderm induction in Xenopus. Information

Substance Name: nodal protein

Registry Number: 0

Grant and Affiliation Information for Endodermal Nodal-related signals and mesoderm induction in Xenopus.

AFFILIATION: Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095-1662, USA.

Country: ENGLAND

AGENCY: United States NICHD

GRANT: R37 HD021502-14

ACRONYM: HD

MEDLINETA: Development

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Endodermal Nodal-related signals and mesoderm induction in Xenopus Related Publications

• An electron microscope analysis of nerves infected with the B virus.
• Assay of thyrotropic hormone in human blood.
• Asymmetric mitosis: Unequal segregation of proteins destined for degradation.
• BMP-binding modules in chordin: a model for signalling regulation in the extracellular space.
• Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.
• Cytological and cytochemical bases of thyroid function.
• Endodermal Nodal-related signals and mesoderm induction in Xenopus.
• Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal.
• Mouse Crossveinless-2 is the vertebrate homolog of a Drosophila extracellular regulator of BMP signaling.
• Neural induction in the absence of organizer in salamanders is mediated by MAPK.
• Postnatal evolution of steroidogenic cells in the chick ovary.
• Proteolytic activity in the physiology, pathology and therapeutics of the thyroid gland.
• The Xenopus homologue of Bicaudal-C is a localized maternal mRNA that can induce endoderm formation.
• The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling.
• The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.
• The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning.
• Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm.
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [The head inducer Cerberus in a multivalent extracellular inhibitor]