Enantioselectivity in estrogenic potential and uptake of bifenthrin.

Enantioselectivity in estrogenic potential and uptake of bifenthrin. Research Abstract Details 

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Enantioselectivity in estrogenic potential and uptake of bifenthrin. Abstract Text:

Lumei Wang,Weiping Liu,Caixia Yang,Zhiyan Pan,Jianying Gan,Chao Xu,Meirong Zhao,Daniel Schlenk,Lumei Wang,Weiping Liu,Caixia Yang,Zhiyan Pan,Jianying Gan,Chao Xu,Meirong Zhao,Daniel Schlenk,Lumei Wang,Weiping Liu,Caixia Yang,Zhiyan Pan,Jianying Gan,Chao Xu,Meirong Zhao,Daniel Schlenk,

Despite the fact that the biological processes of chiral compounds are enantioselective, the endocrine disruption activity and uptake of chiral contaminants with respect to enantioselectivity has so far received limited research. In this study, the estrogenic potential and uptake of the enantiomers of a newer pyrethroid insecticide, bifenthrin (BF), were investigated. Significant differences in estrogenic potential were observed between the two enantiomers in the in vitro human breast carcinoma MCF-7 cell proliferation assay (i.e., the E-SCREEN assay) and the in vivo aquatic vertebrate vitellogenin enzyme-linked immunosorbent assay (ELISA). In the E-SCREEN assay, the relative proliferative effect ratios of 1S-cis-BF and 1R-cis-BF were 74.2% and 20.9%, respectively, and the relative proliferative potency ratios were 10% and 1%, respectively. The cell proliferation induced by the two BF enantiomers may be through the classical estrogen response pathway via the estrogen receptor (ER), as the proliferation induced by the enantiomers could be completely blocked when combined with 10-6 mol/L of the ER antagonist ICI 182,780. Measurement of vitellogenin induction in Japanese medaka (Oryzias latipes) showed that, at an exposure level of 10 ng/mL, the response to 1S-cis-BF was about 123 times greater than thattothe Renantiomer. Significant selectivity also occurred in the uptake of BF enantiomers in the liver and other tissues of J. medaka. These results together suggest that assessment of the environmental safety of chiral insecticides should consider enantioselectivity in acute and chronic ecotoxicities such as endocrine disruption.

Enantioselectivity in estrogenic potential and uptake of bifenthrin. Publishing Authors By Initials

L Wang,W Liu,C Yang,Z Pan,J Gan,C Xu,M Zhao,D Schlenk,L Wang,W Liu,C Yang,Z Pan,J Gan,C Xu,M Zhao,D Schlenk,L Wang,W Liu,C Yang,Z Pan,J Gan,C Xu,M Zhao,D Schlenk,

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Enantioselectivity in estrogenic potential and uptake of bifenthrin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Environmental science & technology

VOLUME: 41

Page Numbers: 6124-8

Journal Abbreviation: Environ. Sci. Technol.

ISSN: 0013-936X

DAY: 1

MONTH: Sep

YEAR: 2007

Enantioselectivity in estrogenic potential and uptake of bifenthrin. Information

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LANGUAGE: eng

NlmUniqueID: 213155

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AFFILIATION: Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou 310032, China.

Country: United States

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MEDLINETA: Environ Sci Technol

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