Enantiomorphic normalization of focally lesioned brains.

Enantiomorphic normalization of focally lesioned brains. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Enantiomorphic normalization of focally lesioned brains. Abstract Text:

Parashkev Nachev,Elizabeth Coulthard,H Rolf ,Christopher Kennard,Masud Husain,Parashkev Nachev,Elizabeth Coulthard,H Rolf ,Christopher Kennard,Masud Husain,

In order to make spatial inferences about the brain across a group of patients, it is usually necessary to employ some means of bringing each brain image into register with either a group mean image or a standard template. In the presence of focal brain lesions, automated methods for performing such so-called normalization are liable to distortion from the abnormal signal within the lesion, especially when the non-linear warping necessary for maximum registration fidelity is used. The most frequently used method for minimizing this distortion - cost function masking - simply eliminates the lesioned area when deriving the normalization parameters. As lesion size increases, however, the normalization error may be expected to rise steeply since the volume of brain from which the parameters are derived falls with it. Here we propose an alternative non-linear registration method that exploits a natural redundancy in the brain - the enantiomorphic relation between the two hemispheres - to correct the signal within the lesion using information from the undamaged homologous region within the contralesional hemisphere. As lesion size increases, the normalization error should theoretically asymptote to inter-hemispheric differences, which are both quantifiable and much lower than the inter-subject difference. Using SPM's non-linear normalization routines, we evaluate this technique with images of normal brains to which lesions selected from a large dataset have been artificially applied. Our results show the enantiomorphic method to be vastly superior to cost function masking across subjects, lesion characteristics, and brain voxels. We therefore propose that it should be the method of choice for normalizing images of focally lesioned brains.

Enantiomorphic normalization of focally lesioned brains. Publishing Authors By Initials

P Nachev,E Coulthard,HR ,C Kennard,M Husain,P Nachev,E Coulthard,HR ,C Kennard,M Husain,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Enantiomorphic normalization of focally lesioned brains. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: NeuroImage

VOLUME: 39

Page Numbers: 1215-26

Journal Abbreviation: Neuroimage

ISSN: 1053-8119

DAY: 12

MONTH: 10

YEAR: 2007

Enantiomorphic normalization of focally lesioned brains. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9215515

Enantiomorphic normalization of focally lesioned brains. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Enantiomorphic normalization of focally lesioned brains. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Enantiomorphic normalization of focally lesioned brains.

AFFILIATION: Department of Clinical Neuroscience, Imperial College London, UK.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neuroimage

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Enantiomorphic normalization of focally lesioned brains Related Publications

• A critical evaluation of "the long case" in final MBBS examination.
• A new commercial strain of ergot adapted from a wild grass.
• An audit on hospital management of bronchial asthma.
• An epidemiologic study of cystitis among Muslim women attending an out-patients clinic in Karachi.
• Anxiety states in general practice.
• Assessment of hairline EEG as a screening tool for nonconvulsive status epilepticus: Response to Bubrick et al.
• Atherosclerotic Ischemic Nephropathy as a Cause of Chronic Kidney Disease: What can be done to Prevent End-stage Renal Disease?
• Battered child syndrome: what should a physician know about it?
• Comparison of mixed liquor filterability measured with bench and pilot-scale membrane bioreactors.
• Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality.
• Decolorization of direct dyes by salt fractionated turnip proteins enhanced in the presence of hydrogen peroxide and redox mediators.
• Dental services in Andhra Pradesh (India).
• Drug dependence in Mekran-Panjgur revisited.
• Enantiomorphic normalization of focally lesioned brains.
• Evalutation of Artemisia annua Strains for Higher Artemisinin Production*.
• Heterotopic glial tissue in tonsil: a case report.
• Measurement and theoretical characterization of electronic absorption spectrum of neutral chrysene (C18H12)and its positive ion in H3BO3 matrix.
• Mini-external fixation of two- and three-part proximal humerus fractures.
• Neural network models of tinnitus.
• Potential of plant polyphenol oxidases in the decolorization and removal of textile and non-textile dyes.
• Primary proliferative glomerulonephritis--a clinicomorphological analysis.
• Region-specific patterns of vascular remodelling occur early in atherosclerosis and without loss of smooth muscle cell markers.
• The Essential Oil of Perilla ocimoides: A Rich Source of Rosefuran.
• The assessment of physiotherapy in the rehabilitation of burns.
• The assessment of physiotherapy in the rehabilitation of burns.
• Typhoid fevers: treatment with lomefloxacin.
• Use of chemical coagulants to control fouling potential for wastewater membrane bioreactor processes.
• Using the key informant method to investigate childhood blindness related to vitamin A deficiency disorder in six rural sub-districts in Bangladesh.
• Variation in Forskolin Content in the Roots of Coleus forskohlii.
• Vascular endothelial oxidative stress in alcohol-induced hypertension.