En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder.

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Research Abstract Details 

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En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Abstract Text:

Michelle A Cheh,James H Millonig,Lauren M Roselli,Xue Ming,Erin Jacobsen,Silky Kamdar,George C Wagner,

Autism spectrum disorder (ASD) is a prevalent and inheritable neurodevelopmental disorder. Recent human genetic studies are consistent with the homeobox transcription factor, ENGRAILED 2 (EN2), being an ASD susceptibility gene. En2 knockout mice (En2(-/-)) display subtle cerebellar neuropathological changes similar to what has been observed in the ASD brain. To investigate whether En2(-/-) mice displayed abnormal behavior relevant to ASD, they were monitored in tasks designed to assess social maturation as well as learning and memory. Deficits in social behavior were detected in En2(-/-) mice across maturation that included decreased play, reduced social sniffing and allogrooming, and less aggressive behavior. Deficits in two spatial learning and memory tasks were also observed. Because locomotor activity was a component of many of the behavioral tasks, this was measured at various stages of development. Locomotor activity was not compromised in the knockout. However, a more thorough analysis of motor behavior in En2(-/-) mice revealed deficits in specific motor tasks. To determine whether neurochemical changes were associated with these behavioral phenotypes, monoamine levels in specific brain regions were assessed. A cerebellar-specific increase in serotonin and its metabolite was observed. Interestingly, several reports have suggested that the serotonin pathway is affected in ASD. We conclude that En2(-/-) mice display behavioral and neurochemical changes, in addition to genetic and neuropathological changes, relevant to ASD. Therefore, these mice may be useful as an animal model of autism.

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Publishing Authors By Initials

MA Cheh,JH Millonig,LM Roselli,X Ming,E Jacobsen,S Kamdar,GC Wagner,

For similar behavior and behavior mechanisms: behavior: social behavior research abstracts see: behavior and behavior mechanisms: behavior: social behavior research

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En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research

VOLUME: 1116

Page Numbers: 166-76

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 28

MONTH: 08

YEAR: 2006

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Information

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LANGUAGE: eng

NlmUniqueID: 45503

En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Keywords Mesh Terms:

KEYWORDS: Social Behavior

MESH TERMS: physiology

Chemical & Substance for Abstract: En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder. Information

Substance Name: engrailed 2 protein

Registry Number: 0

Grant and Affiliation Information for En2 knockout mice display neurobehavioral and neurochemical alterations relevant to autism spectrum disorder.

AFFILIATION: Department of Neuroscience, Rutgers University, New Brunswick, NJ 08901, USA.

Country: Netherlands

AGENCY: United States NINDS

GRANT: NS 43981

ACRONYM: NS

MEDLINETA: Brain Res

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