EMR using dextrose solution versus sodium hyaluronate for colorectal Paris type I and 0-II lesions: a randomized endoscopist-blinded study.

EMR using dextrose solution versus sodium hyaluronate for colorectal Paris type I and 0-II lesions: a randomized endoscopist-blinded study. Research Abstract Details 

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EMR using dextrose solution versus sodium hyaluronate for colorectal Paris type I and 0-II lesions: a randomized endoscopist-blinded study. Abstract Text:

D P Hurlstone,K I Fu,S R Brown,M Thomson,R Atkinson,N Tiffin,S S Cross,D P Hurlstone,K I Fu,S R Brown,M Thomson,R Atkinson,N Tiffin,S S Cross,

BACKGROUND AND AIMS: Loss of mucosal 'lift' prior to submucosal dissection or endoscopic mucosal resection (EMR) increases the risk of complications. We conducted a randomized controlled trial comparing dextrose solution with sodium hyaluronic acid (SHA) for the EN BLOC resection of Paris type I/0-II and lateral spreading lesions of the colorectum. PATIENTS AND METHODS: Patients with Paris type I/0-II or lateral spreading tumor lesions of < 30 mm were randomized in a 1 : 1 ratio to undergo EMR using either dextrose solution or SHA. The primary study outcome was complete resection. Secondary outcomes were endoscopic complications (i. e. perforation or bleeding) and polyp recurrence rates. RESULTS: A total of 174 patients were randomized. R0 resection was achieved in 59 of the 82 lesions (72 %) in the dextrose group and 56 of the 81 lesions (69 %) in the SHA group ( P > 0.1), with no significant difference in median lesion diameter ( P > 0.1). The median number of post resection surveillance colonoscopies was 3 (range 2 - 7) in the dextrose group and 4 (range 2 - 6) in the SHA group ( P = NS). The median post index EMR resection follow-up period was 20 months (range 4 - 26) in the DS group and 18 months (range 3 - 22) in the SHA group ( P = NS). Recurrence rates were 1/82 (1.21 %) in the dextrose group and 1/81 (1.23 %) in the SHA group ( P = NS). CONCLUSIONS: EMR using dextrose solution is as effective as SHA in terms of resection completion, recurrence rates, and complications.

EMR using dextrose solution versus sodium hyaluronate for colorectal Paris type I and 0-II lesions: a randomized endoscopist-blinded study. Publishing Authors By Initials

DP Hurlstone,KI Fu,SR Brown,M Thomson,R Atkinson,N Tiffin,SS Cross,DP Hurlstone,KI Fu,SR Brown,M Thomson,R Atkinson,N Tiffin,SS Cross,

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EMR using dextrose solution versus sodium hyaluronate for colorectal Paris type I and 0-II lesions: a randomized endoscopist-blinded study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endoscopy

VOLUME: 40

Page Numbers: 110-4

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ISSN: 1438-8812

DAY: 6

MONTH: Feb

YEAR: 2008

EMR using dextrose solution versus sodium hyaluronate for colorectal Paris type I and 0-II lesions: a randomized endoscopist-blinded study. Information

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LANGUAGE: eng

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AFFILIATION: Gastroenterology and Liver Unit at Royal Hallamshire Hospital Sheffield, UK. p.hurlstone@shef.ac.uk

Country: Germany

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MEDLINETA: Endoscopy

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