Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity.

Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity. Research Abstract Details 

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Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity. Abstract Text:

Hurlemann,Andreas Matusch,Barbara Hawellek,Dietrich Klingmuller,Heike Kolsch,Wolfgang Maier,Raymond J Dolan, Hurlemann,Andreas Matusch,Barbara Hawellek,Dietrich Klingmuller,Heike Kolsch,Wolfgang Maier,Raymond J Dolan,

RATIONALE: Privileged episodic encoding of an aversive event often comes at a cost of neutral events flanking the aversive event, resulting in decreased episodic memory for these neutral events. This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol. OBJECTIVE: We used a strategy of pharmacologically potentiating cortisol and norepinephrine activity to probe the putative neurochemical substrates of peri-emotional amnesia. MATERIALS AND METHODS: Fifty-four healthy individuals participated in a randomized double-blind placebo-controlled study. Within the experimental context of an established peri-emotional amnesia paradigm, we tested the amnesiogenic potential of hydrocortisone (30 mg p.o.) in the presence or absence of the norepinephrine-reuptake inhibitor reboxetine (4 mg p.o.). RESULTS: Under dual challenge conditions, we observed a linear dose-response relationship in the magnitude and duration of emotion-induced retrograde amnesia. CONCLUSIONS: Our results are consistent with a phenotypic expression of retrograde amnesia varying as a function of norepinephrine and cortisol coactivation during episodic encoding of aversive events. Our study demonstrates that the adverse cognitive and behavioral sequelae of aversive emotion can be experimentally modeled by a pharmacological manipulation of its putative neurochemical substrates.

Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity. Publishing Authors By Initials

R Hurlemann,A Matusch,B Hawellek,D Klingmuller,H Kolsch,W Maier,RJ Dolan,R Hurlemann,A Matusch,B Hawellek,D Klingmuller,H Kolsch,W Maier,RJ Dolan,

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Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychopharmacology

VOLUME: 194

Page Numbers: 261-9

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 24

MONTH: 06

YEAR: 2007

Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity. Information

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LANGUAGE: eng

NlmUniqueID: 7608025

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AFFILIATION: Department of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany. renehurlemann@gmx.de

Country: Germany

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MEDLINETA: Psychopharmacology (Berl)

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