Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Research Abstract Details 

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Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Abstract Text:

Meetha Medhora,Anuradha Dhanasekaran,Stephanie K Gruenloh,Laurel K Dunn,Michael Gabrilovich,John R Falck,David R Harder,Elizabeth R Jacobs,Phillip F Pratt,

Arachidonic acid (AA) is an essential fatty acid that is metabolized by cyclooxygenase (COX), lipoxygenase (LOX) or cytochrome P450 (CYP) enzymes to generate eicosanoids which in turn mediate a number of biological activities including regulation of angiogenesis. While much information on the effects of COX and LOX products is known, the physiological relevance of the CYP-derived products of AA are less well understood. CYP enzymes are highly expressed in the liver and kidney, but have also been detected at lower levels in the brain, heart and vasculature. A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs). This review will focus on the emerging roles of inhibitors of eicosanoid production with emphasis on the CYP pathways, in the regulation of angiogenesis and tumor growth. We also discuss current observations describing the protective effects of EETs for survival of the endothelium.

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Publishing Authors By Initials

M Medhora,A Dhanasekaran,SK Gruenloh,LK Dunn,M Gabrilovich,JR Falck,DR Harder,ER Jacobs,PF Pratt,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: neovascularization, physiologic research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: neovascularization, physiologic research

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Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Journal Published:

PUBLICATION TYPE: Review

Journal: Prostaglandins & other lipid mediators

VOLUME: 82

Page Numbers: 19-29

Journal Abbreviation: Prostaglandins Other Lipid Med

ISSN: 1098-8823

DAY: 25

MONTH: 07

YEAR: 2006

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Information

Number of References: 65

LANGUAGE: eng

NlmUniqueID: 9808648

Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Keywords Mesh Terms:

KEYWORDS: Neovascularization, Physiologic

MESH TERMS: drug effects

Chemical & Substance for Abstract: Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids. Information

Substance Name: Alkane 1-Monooxygenase

Registry Number: EC 1.14.15.3

Grant and Affiliation Information for Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.

AFFILIATION: Division of Pulmonary and Critical Care, Department of Medicine, Medical College of Wisconsin, 8701, Watertown Plank Road, Milwaukee, WI 53226, USA. medhoram@mcw.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL069996

ACRONYM: HL

MEDLINETA: Prostaglandins Other Lipid Med

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