Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction.

Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Research Abstract Details 

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Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Abstract Text:

Alexander S Kauffman,Donald K Clifton,Robert A Steiner,Alexander S Kauffman,Donald K Clifton,Robert A Steiner,Alexander S Kauffman,Donald K Clifton,Robert A Steiner,

Neurons that produce gonadotropin-releasing hormone (GnRH) drive the reproductive axis, but the molecular and cellular mechanisms by which hormonal and environmental signals regulate GnRH secretion remain poorly understood. Kisspeptins are products of the Kiss1 gene, and the interaction of kisspeptin and its receptor GPR54 plays a crucial role in governing the onset of puberty and adult reproductive function. This review discusses the latest ideas about kisspeptin-GPR54 signaling in the neuroendocrine regulation of reproduction, with special emphasis on the role of Kiss1 and kisspeptin in the negative and positive feedback control of gonadotropin secretion by sex steroids, timing of puberty onset, sexual differentiation of the brain and photoperiodic regulation of seasonal reproduction.

Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Publishing Authors By Initials

AS Kauffman,DK Clifton,RA Steiner,AS Kauffman,DK Clifton,RA Steiner,AS Kauffman,DK Clifton,RA Steiner,

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Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Journal Published:

PUBLICATION TYPE: Review

Journal: Trends in neurosciences

VOLUME: 30

Page Numbers: 504-11

Journal Abbreviation: Trends Neurosci.

ISSN: 0166-2236

DAY: 29

MONTH: 09

YEAR: 2007

Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction.

AFFILIATION: Department of Physiology, University of Washington, Seattle, WA 98195, USA.

Country: England

AGENCY: United States NICHD

GRANT: U54 HD12629

ACRONYM: HD

MEDLINETA: Trends Neurosci

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