Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction.

Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Research Abstract Details 

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Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Abstract Text:

Martin,Kevin A Wilkinson,Atsushi Nishimune,Jeremy M Henley, Martin,Kevin A Wilkinson,Atsushi Nishimune,Jeremy M Henley,

Post-translational protein modifications are integral components of signalling cascades that enable cells to efficiently, rapidly and reversibly respond to extracellular stimuli. These modifications have crucial roles in the CNS, where the communication between neurons is particularly complex. SUMOylation is a post-translational modification in which a member of the small ubiquitin-like modifier (SUMO) family of proteins is conjugated to lysine residues in target proteins. It is well established that SUMOylation controls many aspects of nuclear function, but it is now clear that it is also a key determinant in many extranuclear neuronal processes, and it has also been implicated in a wide range of neuropathological conditions.

Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Publishing Authors By Initials

S Martin,KA Wilkinson,A Nishimune,JM Henley,S Martin,KA Wilkinson,A Nishimune,JM Henley,

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Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Journal Published:

PUBLICATION TYPE: Review

Journal: Nature reviews. Neuroscience

VOLUME: 8

Page Numbers: 948-59

Journal Abbreviation: Nat. Rev. Neurosci.

ISSN: 1471-0048

DAY: 20

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK.

Country: England

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Nat Rev Neurosci

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