Emerging concepts towards the development of contraceptive agents.

Emerging concepts towards the development of contraceptive agents. Research Abstract Details 

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Emerging concepts towards the development of contraceptive agents. Abstract Text:

The theoretical background for development of steroid contraceptive agents, LH-RH agonists and antagonists, heterocyclic abortifacients, male contraceptive agents, and contraceptive vaccines are reviewed, with emphasis on basic steroid receptor research. Recent findings confirming the steroid receptor interaction theory proposed in 1960 are described. This model suggests that the steroid enters target cells by diffusion and binds to specific protein receptors in the cytoplasm. The steroid- receptor complex moves to the nucleus by concentration gradient and binds to chromatin or DNA, altering gene expression. both estrogen and progesterone receptors are asymmetric peptides with rigid hydrophobic domains that bind specific steroids, doisynolic acids, stilbenes, gem- diarylethylenes, triarylpropiones, all of which have a set distance between a phenolic hydroxyl and another hydroxyl analogous to the steroid C17-beta-hydroxyl groups. Antiprogestins without glucocorticoid activity are being sought. LH-RH antagonists are being developed by substituting amino acids in the peptide. A large variety of heterocyclic compounds, 26 types, with abortifacient activity, acting by interfering with blastocyst binding to the deciduum is described, such as a series of quinine derivatives. Male antifertility agents must block spermatogenesis without affecting libido or sperm maturation. Combined steroid pills with cyproterone acetate and an androgen are in clinical trials. The most hopeful immunologic contraceptives are vaccines based on part of the beta subunit of hCG, sperm antigens and zona pellucida antigens.

Emerging concepts towards the development of contraceptive agents. Publishing Authors By Initials

For similar proteins: receptors, drug research abstracts see: proteins: receptors, drug research

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Emerging concepts towards the development of contraceptive agents. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in drug research. Fortschritte der Arznei

VOLUME: 33

Page Numbers: 267-315

Journal Abbreviation:

ISSN: 0071-786X

DAY: 25

MONTH: 02

YEAR: 1989

Emerging concepts towards the development of contraceptive agents. Information

Number of References: 283

LANGUAGE: eng

NlmUniqueID: 1304021

Emerging concepts towards the development of contraceptive agents. Keywords Mesh Terms:

KEYWORDS: Receptors, Drug

MESH TERMS: drug effects

Chemical & Substance for Abstract: Emerging concepts towards the development of contraceptive agents. Information

Substance Name: Receptors, Drug

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Country: SWITZERLAND

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MEDLINETA: Prog Drug Res

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