Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age.

Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. Research Abstract Details 

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Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. Abstract Text:

Katalin Szanto,Benoit H Mulsant,Patricia R Houck,Mary Amanda Dew,Alexandre Dombrovski,Bruce G Pollock,Charles F Reynolds,

INTRODUCTION: To determine the rate and clinical correlates of emergent, persistent, and resolved suicidal ideation during treatment of major depression in the elderly. METHODS: Based on the course of suicidal ideation before and during 12 weeks of antidepressant treatment, we classified 437 elderly patients (234 treated with paroxetine; 203 with nortriptyline) as either non-suicidal or as having "emergent", "persistent", or "resolved" suicidality. We compared the four groups on pretreatment demographic and clinical measures and with respect to depression, anxiety, and akathisia during treatment. Results: Rates of emergent, persistent, and resolved suicidality were 7.8%, 12.6%, and 15.6%, respectively. Patients with persistent suicidal ideation were more likely to have recurrent depression than non-suicidal patients or patients whose suicidality resolved with treatment. At the start of treatment, patients in all three suicidal groups had lower self-esteem than non-suicidal patients. During the course of treatment, emergent suicidality was not associated with akathisia, nor did rates of emergent suicidality differ between paroxetine- and nortriptyline-treated patients. While at baseline the levels of depression and anxiety and agitation were similar in the four groups, patients with resolved suicidality had a favorable treatment response, while patients with emergent and persistent suicidality were more likely to maintain higher depression scores and had higher levels of anxiety and agitation during treatment. DISCUSSION: Emergence of suicidal ideation is not common but is clinically significant during treatment of late-life depression and may signal more difficult-to-treat-depression.

Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. Publishing Authors By Initials

K Szanto,BH Mulsant,PR Houck,MA Dew,A Dombrovski,BG Pollock,CF Reynolds,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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MEDLINE DATE:

Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of affective disorders

VOLUME: 98

Page Numbers: 153-61

Journal Abbreviation:

ISSN: 0165-0327

DAY: 24

MONTH: 08

YEAR: 2006

Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906073

Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: statistics & numerical data

Chemical & Substance for Abstract: Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. Information

Substance Name: Antidepressive Agents

Registry Number: 0

Grant and Affiliation Information for Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age.

AFFILIATION: University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania 15213, United States. szantok@upmc.edu

Country: Netherlands

AGENCY: United States NIMH

GRANT: R37 MH43832

ACRONYM: MH

MEDLINETA: J Affect Disord

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