Emergence of multiplicative auditory responses in the midbrain of the barn owl.

Emergence of multiplicative auditory responses in the midbrain of the barn owl. Research Abstract Details 

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Emergence of multiplicative auditory responses in the midbrain of the barn owl. Abstract Text:

Brian J Fischer, ,Masakazu Konishi,Brian J Fischer, ,Masakazu Konishi,

Space-specific neurons in the barn owl's auditory space map gain spatial selectivity through tuning to combinations of the interaural time difference (ITD) and interaural level difference (ILD). The combination of ITD and ILD in the subthreshold responses of space-specific neurons in the external nucleus of the inferior colliculus (ICx) is well described by a multiplication of ITD- and ILD-dependent components. It is unknown, however, how ITD and ILD are combined at the site of ITD and ILD convergence in the lateral shell of the central nucleus of the inferior colliculus (ICcl) and therefore whether ICx is the first site in the auditory pathway where multiplicative tuning to ITD- and ILD-dependent signals occurs. We used extracellular recording of single neurons to determine how ITD and ILD are combined in ICcl of the anesthetized barn owl (Tyto alba). A comparison of additive, multiplicative, and linear-threshold models of neural responses shows that ITD and ILD are combined nonlinearly in ICcl, but the interaction of ITD and ILD is not uniformly multiplicative over the sample. A subset (61%) of the neural responses is well described by the multiplicative model, indicating that ICcl is the first site where multiplicative tuning to ITD- and ILD-dependent signals occurs. ICx, however, is the first site where multiplicative tuning is observed consistently. A network model shows that a linear combination of ICcl responses to ITD-ILD pairs is sufficient to produce the multiplicative subthreshold responses to ITD and ILD seen in ICx.

Emergence of multiplicative auditory responses in the midbrain of the barn owl. Publishing Authors By Initials

BJ Fischer,JL ,M Konishi,BJ Fischer,JL ,M Konishi,

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Emergence of multiplicative auditory responses in the midbrain of the barn owl. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurophysiology

VOLUME: 98

Page Numbers: 1181-93

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 5

MONTH: 07

YEAR: 2007

Emergence of multiplicative auditory responses in the midbrain of the barn owl. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Emergence of multiplicative auditory responses in the midbrain of the barn owl.

AFFILIATION: California Institute of Technology, Division of Biology, Mail code 216-76, 1200 E. California, Pasadena, CA 91125, USA. fischerb@caltech.edu

Country: United States

AGENCY: United States NIDCD

GRANT: DC-007690

ACRONYM: DC

MEDLINETA: J Neurophysiol

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