Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa.

Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa. Research Abstract Details 

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Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa. Abstract Text:

Several different Guiana extended-spectrum (GES) enzymes have been described occurring in Enterobacteriaceae and Pseudomonas aeruginosa worldwide. Polymerase chain reaction and gene sequencing analysis confirmed bla(GES) genes identified in three P. aeruginosa clinical isolates from South Africa as bla(GES-5) and bla(GES-5)-like, respectively. Compared with GES-1, the GES-5-like protein exhibited an A21E amino acid change, a novel mutation not previously described in this family. Integron structures identified upstream from the bla(GES-5) and bla(GES-5)-like genes were found to be identical to bla(GES-2)-carrying integrons described previously from the same geographical region. These findings confirm the establishment and persistence of integron-associated GES-type extended-spectrum beta-lactamases (ESBLs) in the South African nosocomial environment. This study describes the first isolation of class 1 integron-associated bla(GES-5) and the emergence of a novel GES-5-like ESBL in South Africa.

Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa. Publishing Authors By Initials

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Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of antimicrobial agents

VOLUME: 31

Page Numbers: 527-30

Journal Abbreviation: Int. J. Antimicrob. Agents

ISSN: 0924-8579

DAY: 23

MONTH: 04

YEAR: 2008

Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa. Information

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LANGUAGE: eng

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Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa. Keywords Mesh Terms:

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Grant and Affiliation Information for Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa.

AFFILIATION: Inqaba Biotechnical Industries, Pretoria, South Africa; Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Country: Netherlands

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MEDLINETA: Int J Antimicrob Agents

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