Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans.

Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans. Research Abstract Details 

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Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans. Abstract Text:

E A Olmsted,F H Gannon,Z Q Wang,A E Grigoriadis,E F Wagner,M A Zasloff,E M Shore,F S Kaplan,

Murine embryonic overexpression of the c-fos protooncogene leads to early postnatal heterotopic chondrogenesis and osteogenesis with phenotypic features similar to those seen in children who have the disabling heritable disease fibrodysplasia ossificans progressiva. The overexpression of Fos in embryonic stem cell chimeras leads to heterotopic endochondral osteogenesis at least in part through a bone morphogenetic protein 4 mediated signal transduction pathway. In contrast, early fibrodysplasia ossificans progressiva lesions express abundant bone morphogenetic protein 4, without abundant expression of c-Fos, suggesting that the primary molecular defect in fibrodysplasia ossificans progressiva may be independent of the sustained Fos effects on chondrogenesis and osteogenesis. Comparisons of the clinical, molecular, and pathogenetic features of the c-Fos embryonic stem cell chimeras with those of fibrodysplasia ossificans progressiva provide insight into the earliest events in the molecular pathogenesis of genetically induced heterotopic chondrogenesis and osteogenesis. The relevance of the c-Fos embryonic stem cell chimera to the study of the currently untreatable human disease fibrodysplasia ossificans progressiva demonstrates the power of using embryonic stem cell technology for generating gain of function mutations in the study of human bone disease.

Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans. Publishing Authors By Initials

EA Olmsted,FH Gannon,ZQ Wang,AE Grigoriadis,EF Wagner,MA Zasloff,EM Shore,FS Kaplan,

For similar animals: animal population groups: chimera: transplantation chimera research abstracts see: animals: animal population groups: chimera: transplantation chimera research

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Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical orthopaedics and related research

VOLUME:

Page Numbers: 81-94

Journal Abbreviation: Clin. Orthop. Relat. Res.

ISSN: 0009-921X

DAY: 19

MONTH: Jan

YEAR: 1998

Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans. Information

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LANGUAGE: eng

NlmUniqueID: 75674

Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans. Keywords Mesh Terms:

KEYWORDS: Transplantation Chimera

MESH TERMS: physiology

Chemical & Substance for Abstract: Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans. Information

Substance Name: bone morphogenetic protein 4

Registry Number: 0

Grant and Affiliation Information for Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans.

AFFILIATION: Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

Country: UNITED STATES

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MEDLINETA: Clin Orthop Relat Res

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