EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans.

EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Research Abstract Details 

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EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Abstract Text:

Iskra Katic,Iva Greenwald,

The sel-6 gene was previously identified in a screen for suppressors of the egg-laying defect associated with hypermorphic alleles of lin-12 (Tax et al. 1997). Here we show that sel-6 and two other previously defined genes, mal-2 and emb-4, are the same gene, now called "emb-4." We perform a genetic and molecular characterization of emb-4 and show that it functions cell autonomously as a positive regulator of lin-12 activity. Viable alleles identified as suppressors of lin-12 are partial loss-of-function mutations, whereas the null phenotype encompasses a range of lethal terminal phenotypes that apparently are not related to loss of lin-12/Notch signaling. emb-4 encodes a large nuclearly localized protein containing a predicted ATPase domain and has apparent orthologs in fission yeast, plants, and animals.

EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Publishing Authors By Initials

I Katic,I Greenwald,

For similar urogenital system: genitalia: genitalia, female: vulva research abstracts see: urogenital system: genitalia: genitalia, female: vulva research

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EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genetics

VOLUME: 174

Page Numbers: 1907-15

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 9

MONTH: 10

YEAR: 2006

EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374636

EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Keywords Mesh Terms:

KEYWORDS: Vulva

MESH TERMS: metabolism

Chemical & Substance for Abstract: EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans. Information

Substance Name: Adenosine Triphosphatases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for EMB-4: a predicted ATPase that facilitates lin-12 activity in Caenorhabditis elegans.

AFFILIATION: Department of Genetics and Development, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA095389

ACRONYM: CA

MEDLINETA: Genetics

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