Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates.

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Research Abstract Details 

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Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Abstract Text:

Marc M Greenberg,

DNA damage is a double-edged sword. The modifications produced in the biopolymer are associated with aging, and give rise to a variety of diseases, including cancer. DNA is also the target of anti-tumor agents and the most generally used nonsurgical treatment of cancer, ionizing radiation. Agents that damage DNA produce a variety of radicals. Elucidating the chemistry of individual DNA radicals is challenging due to the availability of multiple reactive pathways and complexities inherent with carrying out mechanistic studies on a heterogeneous polymer. The ability to independently generate radicals and their metastable products at defined sites in DNA has greatly facilitated understanding this biologically important chemistry.

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Publishing Authors By Initials

MM Greenberg,

For similar organic chemicals: carboxylic acids: acids, acyclic: sugar acids research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: sugar acids research

PUBMED ID PMID:

MEDLINE DATE:

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Journal Published:

PUBLICATION TYPE: Review

Journal: Organic & biomolecular chemistry

VOLUME: 5

Page Numbers: 18-30

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 14

MONTH: 11

YEAR: 2006

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Information

Number of References: 106

LANGUAGE: eng

NlmUniqueID: 101154995

Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Keywords Mesh Terms:

KEYWORDS: Sugar Acids

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Elucidating DNA damage and repair processes by independently generating reactive and metastable intermediates.

AFFILIATION: Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA. mgreenberg@jhu.edu

Country: England

AGENCY: United States NIGMS

GRANT: GM-063028

ACRONYM: GM

MEDLINETA: Org Biomol Chem

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