Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue.

Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. Abstract Text:

Allen G Li,Matthew J Quinn,Yasmin Siddiqui,Michael D Wood,Isaac F Federiuk,Heather M Duman,W Kenneth Ward,

Foreign body encapsulation represents a chronic fibrotic response and has been a major obstacle that reduces the useful life of implanted biomedical devices. The precise mechanism underlying such an encapsulation is still unknown. We hypothesized that, considering its central role in many other fibrotic conditions, transforming growth factor beta (TGFbeta) may play an important role during the formation of foreign body capsule (FBC). In the present study, we implanted mock sensors in rats subcutaneously and excised FBC samples at day 7, 21, and 48-55 postimplantation. The most abundant TGFbeta isoform in all tissues was TGFbeta1, which was expressed minimally in control tissue. The expression of both TGFbeta1 RNA and protein was significantly increased in FBC tissues at all time points, with the highest level in day 7 FBC. The number of cells stained for phosphorylated Smad2, an indication of activated TGFbeta signaling, paralleled the expression of TGFbeta. A similar dynamic change was also observed in the numbers of FBC myofibroblasts, which in response to TGFbeta, differentiate from quiescent fibroblasts and synthesize collagen. Type I collagen, the most prominent downstream target of TGFbeta in fibrosis, was found in abundance in the FBC, especially during the latter time periods. We suggest that TGFbeta plays an important role in the FBC formation. Inhibition of TGFbeta signaling could be a promising strategy in the prevention of FBC formation, thereby extending the useful life of subcutaneous implants.

Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. Publishing Authors By Initials

AG Li,MJ Quinn,Y Siddiqui,MD Wood,IF Federiuk,HM Duman,WK Ward,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta: transforming growth factor beta1 research

PUBMED ID PMID:

MEDLINE DATE:

Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomedical materials research. Part A

VOLUME: 82

Page Numbers: 498-508

Journal Abbreviation:

ISSN: 1549-3296

DAY: 3

MONTH: Aug

YEAR: 2007

Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta1

MESH TERMS: metabolism

Chemical & Substance for Abstract: Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue. Information

Substance Name: Transforming Growth Factor beta1

Registry Number: 0

Grant and Affiliation Information for Elevation of transforming growth factor beta (TGFbeta) and its downstream mediators in subcutaneous foreign body capsule tissue.

AFFILIATION: Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: R01 EB000743

ACRONYM: EB

MEDLINETA: J Biomed Mater Res A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Elevation of transforming growth factor beta TGFbeta and its downstream mediators in subcutaneous foreign body capsule tissue Related Publications

• A model for the function of sperm DNA degradation.
• Adenovirus-Mediated In Vivo Silencing of Anaphylatoxin Receptor C5aR.
• Analyses of TCR clustering at the T cell-antigen-presenting cell interface and its impact on the activation of naive CD4+ T cells.
• Analysis of a Scottish founder effect narrows the TAPVR-1 gene interval to chromosome 4q12.
• Comparison of reproductive performance in Belgian dairy and beef cattle.
• Diagnosis of lymphogranuloma venereum from biopsy samples.
• Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies.
• Early steps in the biosynthesis of MUC2 epithelial mucin in colon cancer cells.
• Feedback regulation of murine autoimmunity via dominant anti-inflammatory effects of interferon gamma.
• Heart sounds separation from lung sounds using independent component analysis.
• Identification of PhIL1, a novel cytoskeletal protein of the Toxoplasma gondii pellicle, through photosensitized labeling with 5-[125I]iodonaphthalene-1-azide.
• Immunization administration and disease reporting in the emergency department.
• In vitro methylation of specific regions in recombinant DNA constructs by excision and religation.
• In vivo regulation of neutrophil apoptosis by C5a during sepsis.
• Interstitial cells of Cajal: a new perspective on smooth muscle function.
• Is cycloxygenase-2 (COX-2) a major component of the mechanism responsible for microvascular remodeling in the brain?
• Kit mutants and gastrointestinal physiology.
• Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract.
• Measurement of perceived school climate for active travel in children.
• Microarray technology in biomedical research.
• Monoclonal antibodies reacting with the MUC2 mucin core protein.
• Pathology services. Down the tubes.
• Precancer in mice: animal models used to understand, prevent, and treat human precancers.
• Relationships between days post partum, observed estrus and uterine microflora in commercial dairy cows.
• Selectin inhibition modulates NF-kappa B and AP-1 signaling after liver ischemia/reperfusion.
• Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication.
• Sperm chromatin remodeling after intracytoplasmic sperm injection differs from that of in vitro fertilization.
• The disconnect between animal models of sepsis and human sepsis.
• The influence of energy intake and percentage of body fat on the reproductive performance of nonpregnant mares.
• Topoisomerase IIB and an extracellular nuclease interact to digest sperm DNA in an apoptotic-like manner.