Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats: a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure.

Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats: a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure. Research Abstract Details 

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Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats: a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure. Abstract Text:

Maoquan Li,Yanyan Wang,Yanwen Zhang,Zhou Zhou,Zhengping Yu,

The goal of this study was to investigate whether glucocorticoids (GCs) take part in cognition impairment after exposure to chronic low-power-density microwave (MW) fields. We exposed Wistar rats to a 2.45-GHz pulsed MW field at an average power density of 1 mW/cm(2) for 3 h daily, for up to 30 days. Our results show that MW-exposed rats had significant deficits in spatial learning and memory performance. MW exposure increased levels of plasma corticosterone, and consequently GC receptor (GR) nuclear translocation and apoptosis in the hippocampus. However, co-administration of the GR antagonist RU486 with MW exposure partially reversed the cognitive impairment and neuronal loss. These data indicate that GCs might contribute to the cognition deficit induced by chronic low-power-density MW exposure.

Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats: a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure. Publishing Authors By Initials

M Li,Y Wang,Y Zhang,Z Zhou,Z Yu,

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Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats: a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of radiation research

VOLUME: 49

Page Numbers: 163-70

Journal Abbreviation: J. Radiat. Res.

ISSN: 0449-3060

DAY: 16

MONTH: 01

YEAR: 2008

Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats: a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Elevation of Plasma Corticosterone Levels and Hippocampal Glucocorticoid Receptor Translocation in Rats: a Potential Mechanism for Cognition Impairment Following Chronic Low-power-density Microwave Exposure.

AFFILIATION: Department of Public Health, Chengdu Medical College.

Country: Japan

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MEDLINETA: J Radiat Res (Tokyo)

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