Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients.

Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients. Research Abstract Details 

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Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients. Abstract Text:

Harutoshi Tamura,Osamu Hirono,Hidenobu Okuyama,Ling Liu,Satoshi Nishiyama,Yasuchika Takeishi,Takamasa Kayama,Isao Kubota,Harutoshi Tamura,Osamu Hirono,Hidenobu Okuyama,Ling Liu,Satoshi Nishiyama,Yasuchika Takeishi,Takamasa Kayama,Isao Kubota,

BACKGROUND: Serum fibrin-monomer (FM) is a precursor of stable fibrin, and is a sensitive marker of a systemic hypercoagulable state. It has been reported that, in patients with acute ischemic stroke, higher levels of serum FM reflect intracardiac thrombus formation. METHODS AND RESULTS: Serum coagulation and fibrinolytic activity were measured in 113 patients with acute ischemic stroke within 7 (6+/-1) days after onset. The patients were followed for a mean of 354 (range 36-585) days. The primary endpoints were ischemic stroke recurrence with/without death. FM was markedly higher in the 19 cases with stroke recurrence (49.6+/-53.6 microg/ml) than in the 94 patients without stroke recurrence (14.6+/-30.5 microg/ml; p=0.008). The cerebrovascular event rates were markedly higher in the 12 cases with FM > or =16.5 microg/ml (37.5%) than in the 7 cases with FM <16.5 microg/ml (8.6%; p<0.001). Cox proportional hazards multivariate analysis showed that the FM level was an independent predictor of ischemic stroke recurrence with/without death (hazard ratio, 1.516 per + 1 standard deviation increase; 95% confidence interval, 1.042-2.180; p=0.036). CONCLUSIONS: Elevated serum FM levels in hospitalized ischemic stroke patients may be associated with a persistent systemic hypercoagulable state and high long-term rates of cerebrovascular events.

Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients. Publishing Authors By Initials

H Tamura,O Hirono,H Okuyama,L Liu,S Nishiyama,Y Takeishi,T Kayama,I Kubota,H Tamura,O Hirono,H Okuyama,L Liu,S Nishiyama,Y Takeishi,T Kayama,I Kubota,

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Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Circulation journal : official journal of the Japa

VOLUME: 71

Page Numbers: 1573-9

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 26

MONTH: Oct

YEAR: 2007

Elevated serum fibrin-monomer levels are associated with high long-term cerebrovascular event rates in acute ischemic stroke patients. Information

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LANGUAGE: eng

NlmUniqueID: 101137683

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AFFILIATION: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan.

Country: Japan

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MEDLINETA: Circ J

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