Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque.

Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. Research Abstract Details 

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Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. Abstract Text:

Keishi Miyata,Masafumi Nakayama,Shoko Mizuta,Seiji Hokimoto,Koichi Sugamura,Shuichi Oshima,Yuichi Oike,Seigo Sugiyama,Hisao Ogawa,Ken-ichi Yamamura,Keishi Miyata,Masafumi Nakayama,Shoko Mizuta,Seiji Hokimoto,Koichi Sugamura,Shuichi Oshima,Yuichi Oike,Seigo Sugiyama,Hisao Ogawa,Ken-ichi Yamamura,

We previously reported that the mouse alpha/beta hydrolase domain containing 2 (Abhd2) was expressed in smooth muscle cells (SMCs) which suppressed their migration and inhibited the development of intimal hyperplasia by cuff placement; however, the role of ABHD2 in human remains to be elucidated. In this study, we examined ABHD2 expression in the human coronary atherosclerotic lesions of the patients with unstable angina (UA) and stable angina (SA). Our results showed that the ABHD2 was expressed in atherosclerotic lesions, and that the ABHD2 expression was significantly higher in the patients with UA than with SA. Immunohistochemistry analysis revealed abundant expression of ABHD2 in macrophages, but low expression in SMCs of atherosclerotic lesions. Using human vascular primary culture cell lines, we also demonstrated that the expression of ABHD2 was significantly higher in macrophages than in SMCs, and that the expression of ABHD2 significantly increased proportionally with differentiation from monocyte into macrophage.

Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. Publishing Authors By Initials

K Miyata,M Nakayama,S Mizuta,S Hokimoto,K Sugamura,S Oshima,Y Oike,S Sugiyama,H Ogawa,K Yamamura,K Miyata,M Nakayama,S Mizuta,S Hokimoto,K Sugamura,S Oshima,Y Oike,S Sugiyama,H Ogawa,K Yamamura,

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Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 365

Page Numbers: 207-13

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 31

MONTH: 10

YEAR: 2007

Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque.

AFFILIATION: Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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